Anti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injury

Basit Öğe Kaydı
dc.authorwosidaydin, ibrahim/ABG-8543-2021
dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.contributor.authorPergel, Ahmet
dc.contributor.authorKanter, Mehmet
dc.contributor.authorYucel, Ahmet Fikret
dc.contributor.authorAydin, Ibrahim
dc.contributor.authorErboga, Mustafa
dc.contributor.authorGuzel, Ahmet
dc.date.accessioned2024-06-12T11:03:57Z
dc.date.available2024-06-12T11:03:57Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective effects of infliximab on oxidative stress, cell proliferation and apoptosis in the rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: sham, I/R and I/R+ infliximab; each group comprised 10 animals. Sham group animals underwent laparotomy without I/R injury. I/R groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation occurred, which was followed by 1 hour of reperfusion. In the infliximab group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously. All animals were killed at the end of reperfusion and intestinal tissues samples were obtained for biochemical and histopathological investigation in all groups. To date, no biochemical and histopathological changes have been reported regarding intestinal I/R injury in rats due to infliximab treatment. Infliximab treatment significantly decreased the elevated tissue malondialdehyde levels and increased reduced superoxide dismutase and glutathione peroxidase enzyme activities in intestinal tissues samples. I/R caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Infliximab treatment significantly attenuated the severity of intestinal I/R injury, inhibiting I/R-induced apoptosis, and cell proliferation. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on the experimental intestinal I/R model of rats.en_US
dc.identifier.doi10.1177/0748233711427056
dc.identifier.endpage932en_US
dc.identifier.issn0748-2337
dc.identifier.issue10en_US
dc.identifier.pmid22082824en_US
dc.identifier.scopus2-s2.0-84865616419en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage923en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711427056
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21854
dc.identifier.volume28en_US
dc.identifier.wosWOS:000310161700008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemia/Reperfusion (I/R)en_US
dc.subjectOxidative Stress And Inflammationen_US
dc.subjectProliferation And Apoptosisen_US
dc.subjectInfliximaben_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectFibroblast-Growth-Factoren_US
dc.subjectCell-Deathen_US
dc.subjectNeutrophil Infiltrationen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxygen Radicalsen_US
dc.subjectAlpha Therapyen_US
dc.subjectApoptosisen_US
dc.subjectPretreatmenten_US
dc.subjectMechanismen_US
dc.titleAnti-inflammatory and antioxidant effects of infliximab in a rat model of intestinal ischemia/reperfusion injuryen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu