Efficacy of doxycycline release collagen membrane on surgically created and contaminated defects in rat tibiae: A histopathological and microbiological study

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dc.authoridErdogan Bamac, Ozge/0000-0002-0352-4841
dc.authoridGurel, Aydin/0000-0002-0266-8771
dc.authoridDUYGU, Gonca/0000-0002-5564-5776
dc.authoridbilge, ipek/0000-0002-0242-7716
dc.authoridOzcakir-Tomruk, Ceyda/0000-0003-1545-5588
dc.authorwosidErdogan Bamac, Ozge/D-8387-2019
dc.authorwosidGurel, Aydin/D-7591-2019
dc.contributor.authorKutan, Esma
dc.contributor.authorDuygu-Capar, Gonca
dc.contributor.authorOzcakir-Tomruk, Cedya
dc.contributor.authorDilek, Ozkan Cem
dc.contributor.authorOzen, Fatma
dc.contributor.authorErodogan, Ozge
dc.contributor.authorOzdemir, Ipek
dc.date.accessioned2024-06-12T10:59:48Z
dc.date.available2024-06-12T10:59:48Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The effects of systemic antibiotics on controlling infective pathogens after guided bone regeneration(GBR) procedures especially in membrane exposures are limited. However, local administrations of antibiotics are rare in GBR techniques. Aim: The aim of this study was to investigate the osteogenesis potential and the antibacterial effect of a doxycycline releasing collagen membrane in surgically created and contaminated defects in rat tibiae. Material and methods: Defects were created in 20 rats that wer randomly divided in to two groups: control group (defect contaminated by Porphyromonas gingivalis, filled with bone graft and covered by collagen membrane); test group (defect contaminated by P. gingivalis filled with bone graft and covered by collagen membrane containing 1 mg/cm(2) doxycycline. Animals were sacrificed post surgically on the 14th day for microbiologic evaluation and on the 28th day for histopathological evaluation. Results: The degree of osteogenesis in the test group was seen to be significantly higher than control group (p: 0.011; p <0.05). Furthermore in test group, no bacterial growth was observed. The bacteria counts were determined between 1 x 104 and 268 x 104 CFU/g with a median of 1.32 x 104 for control group. Conclusions: Within the limitations of this study, the results of the present study suggests that the use of a doxycycline releasing membrane has a positive effect on contaminated GBR procedures for limiting P. gingivalis infections leading to bone formation following GBR procedures in a rat model. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.archoralbio.2015.11.001
dc.identifier.endpage21en_US
dc.identifier.issn0003-9969
dc.identifier.issn1879-1506
dc.identifier.pmid26658367en_US
dc.identifier.scopus2-s2.0-84949032651en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2015.11.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20586
dc.identifier.volume63en_US
dc.identifier.wosWOS:000370833500003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofArchives Of Oral Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDoxycyclineen_US
dc.subjectRat Tibiaeen_US
dc.subjectGuided Bone Regenerationen_US
dc.subjectPorphyromonas Gingivalisen_US
dc.subjectGuided Tissue Regenerationen_US
dc.subjectLoaded Biodegradable Membraneen_US
dc.subjectFurcation Defectsen_US
dc.subjectBarrier Membranesen_US
dc.subjectBone Regenerationen_US
dc.subjectBiocompatibilityen_US
dc.subjectPeriodontitisen_US
dc.subjectAntibioticsen_US
dc.subjectExposureen_US
dc.subjectLesionsen_US
dc.titleEfficacy of doxycycline release collagen membrane on surgically created and contaminated defects in rat tibiae: A histopathological and microbiological studyen_US
dc.typeArticleen_US

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