Does Hypochlorous Acid Cause Ototoxicity? An Experimental Study

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dc.authoridmutlu, ahmet/0000-0001-9022-921X
dc.authoridErsoy, Onur/0000-0001-9829-7903;
dc.authorwosidmutlu, ahmet/AAI-2097-2019
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.authorwosidBULUT, Erdoğan/C-4135-2015
dc.authorwosidKalcioglu, M. Tayyar/JAC-1515-2023
dc.contributor.authorMutlu, Ahmet
dc.contributor.authorGunduz, Ayse Yasemin
dc.contributor.authorBakici Balci, Burcu
dc.contributor.authorErinc, Murat
dc.contributor.authorBulut, Erdogan
dc.contributor.authorErsoy, Onur
dc.contributor.authorKalcioglu, Mahmut Tayyar
dc.date.accessioned2024-06-12T10:52:53Z
dc.date.available2024-06-12T10:52:53Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAimHypochlorous acid (HOCl) is a weak acid that ionizes in water. It is an effective antiseptic exhibiting low toxicity on living tissues. We aimed to investigate the ototoxic effects of HOCl on an animal model by using electrophysiological and histological methods.Materials and MethodsThe study comprised 32 Sprague-Dawley rats, which were separated into four groups: control group (A), saline solution group (B), 70% isopropyl alcohol + 2% chlorhexidine group (C), and HOCl group (D). After recording the auditory brainstem response (ABR) for basal hearing thresholds (8, 16, 24, and 32 kHz), 0.03 ml of the aforementioned materials was injected intratympanically three times every 2 days in groups B, C, and D. ABR measurements were repeated on the 7th and 21st days. All animals were sacrificed, and temporal bones were prepared for examinations of cochlear histology and vascular endothelial growth factor immunohistochemistry.ResultsBasal hearing levels were normal across all frequencies and groups, with no statistical differentiation. On the 7th and 21st days after the ABR test, all other groups demonstrated a significant deterioration in hearing levels compared with group A. When the results from 7th and 21st days were compared within group D, a partial recovery was observed. In histopathology, groups C and D demonstrated moderate and severe cochlear degeneration, along with decreased immunoreactivity in the organ of Corti, stria vascularis, and spiral ligament.ConclusionThis is the first study to evaluate the safety of using HOCl in otology. Although HOCI is less ototoxic than the disinfectant used, it may have a toxic effect on cochlea.en_US
dc.description.sponsorshipNHP (Natural Health Product) drug companyen_US
dc.description.sponsorshipThis study was supported by NHP (Natural Health Product) drug company.en_US
dc.identifier.doi10.1097/MAO.0000000000003734
dc.identifier.endpageE1193en_US
dc.identifier.issn1531-7129
dc.identifier.issn1537-4505
dc.identifier.issue10en_US
dc.identifier.pmid36351230en_US
dc.identifier.scopus2-s2.0-85141451050en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE1187en_US
dc.identifier.urihttps://doi.org/10.1097/MAO.0000000000003734
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18869
dc.identifier.volume43en_US
dc.identifier.wosWOS:000886095400034en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofOtology & Neurotologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAuditory Brainstem Responseen_US
dc.subjectCochleaen_US
dc.subjectHypochlorous Aciden_US
dc.subjectIntratympanic Injectionen_US
dc.subjectOtotoxicityen_US
dc.subjectSprague-Dawley Raten_US
dc.subjectScanning-Electron-Microscopyen_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectOuter Hair-Cellsen_US
dc.subjectNasal Irrigationen_US
dc.subjectReceptorsen_US
dc.subjectToxicityen_US
dc.subjectCochleaen_US
dc.subjectDamageen_US
dc.subjectEaren_US
dc.titleDoes Hypochlorous Acid Cause Ototoxicity? An Experimental Studyen_US
dc.typeArticleen_US

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