Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis

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dc.contributor.authorTasdogan, Muhittin
dc.contributor.authorMemis, Dilek
dc.contributor.authorSut, Necdet
dc.contributor.authorYuksel, Mahmut
dc.date.accessioned2024-06-12T10:50:14Z
dc.date.available2024-06-12T10:50:14Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractStudy Objective: To compare the effects of an intravenous infusion of propofol and the alpha-2 adrenoceptor, dexmedetomidine, on inflammatory responses and intraabdominal pressure (LAP) in severe sepsis after abdominal surgery, specifically, serum cytokine levels (interleukin [IL]-1, IL-6, and tumor necrosis factor [TNF]-alpha) and IAP. Design: Prospective, single-center study. Setting: University hospital. Patients: 40 adult ICU patients who had undergone ileus surgery and who were expected to require postoperative sedation and ventilation. Interventions: Patients received either a loading dose infusion of propofol (Group P; n = 20) one mg/kg over 15 minutes followed by a maintenance dose of one to three mg/kg/hr (n = 20, Group P) or a loading dose of dexmedetomidine of one mu g/kg over 10 minutes followed by a maintenance dose of 0.2-2.5 mu g/kg/h (n = 20, Group D) at the 24th hour. Measurements: Biochemical and hemodynamic parameters, cytokine levels, and IAP were recorded before the start of the study and at the 24th and 48th hours. Main Results: TNF-alpha levels were significantly lower at the 24th hour (14.66 +/- 4.40 pg/mL vs. 21.21 +/- 11.37 pg/mL, respectively) and at the 48th hour (21.25 +/- 15.85 pg/mL vs. 46.55 +/- 35.99 pg/mL, respectively) in Group D. IL-1 levels were significantly lower at the 24th hour (5.03 +/- 0.15 pg/mL vs. 6.23 +/- 2.09 pg/mL, respectively) and the 48th hour (5.01 +/- 0.37 pg/mL vs. 6.42 +/- 2.76 pg/mL, respectively) in Group D. IL-6 levels were significantly lower at the 24th hour (253.1 +/- 303.6 pg/mL and 511.3 +/- 374.8 pg/mL, respectively) and at the 48th hour (343.5 +/- 393.4 pg/rnL and 503.7 +/- 306.4 pg/mL, respectively) in Group D. Intraabdominal pressure also was significantly lower at the 24th hour (12.35 +/- 5.84 mmHg vs, 18.1 +/- 2.84 mmHg, respectively) and the 48th hour (13.9 +/- 6.15 mmHg vs. 18.7 +/- 3.46 mmHg, respectively) in Group D. Conclusion: Dexmedetomidine infusion decreases TNF-a, IL-1, and IL-6 levels and IAP more than a propofol infusion. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipUniversity of Trakya Research, Edime, Turkey [TUBAP 666]en_US
dc.description.sponsorshipSupported by University of Trakya Research Grant No. TUBAP 666, Edime, Turkey.en_US
dc.identifier.doi10.1016/j.jclinane.2008.10.010
dc.identifier.endpage400en_US
dc.identifier.issn0952-8180
dc.identifier.issn1873-4529
dc.identifier.issue6en_US
dc.identifier.pmid19833271en_US
dc.identifier.scopus2-s2.0-70349742451en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage394en_US
dc.identifier.urihttps://doi.org/10.1016/j.jclinane.2008.10.010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17925
dc.identifier.volume21en_US
dc.identifier.wosWOS:000271112400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Clinical Anesthesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal Surgeryen_US
dc.subjectCytokine Levelsen_US
dc.subjectDexmedetomidineen_US
dc.subjectInflammatory Responseen_US
dc.subjectIntraabdominal Pressureen_US
dc.subjectPropofolen_US
dc.subjectSevere Sepsisen_US
dc.subjectAbdominal Compartment Syndromeen_US
dc.subjectInduced Muscular Rigidityen_US
dc.subjectCritically-Illen_US
dc.subjectInternational-Conferenceen_US
dc.subjectHypertensionen_US
dc.subjectInvolvementen_US
dc.subjectPainen_US
dc.subjectMulticenteren_US
dc.subjectValidationen_US
dc.subjectMidazolamen_US
dc.titleResults of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsisen_US
dc.typeArticleen_US

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