Infective Complications After Prostate Biopsy: Outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, A Prospective Multinational Multicentre Prostate Biopsy Study

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dc.authoridSofronievska Glavinov, Maja/0000-0002-7857-6056
dc.authoridPereira, Bruno Jorge/0000-0001-6537-1388
dc.authoridHeldwein, Flavio Lobo/0000-0003-4321-0078
dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authoridStaneloni, Maria Ines/0000-0001-8259-7215
dc.authoridLodde, Michele/0000-0001-8813-318X
dc.authoridSacco, Emilio/0000-0003-4640-8354
dc.authorwosidSofronievska Glavinov, Maja/ABC-9014-2020
dc.authorwosidAdamczyk, Przemyslaw/AFF-9381-2022
dc.authorwosidPereira, Bruno Jorge/J-1371-2019
dc.authorwosidNaber, Kurt/AAR-9997-2020
dc.authorwosidAdamczyk, Przemyslaw/AAF-1116-2022
dc.authorwosidHeldwein, Flavio Lobo/G-9603-2013
dc.authorwosidArda, Ersan/L-7357-2016
dc.contributor.authorWagenlehner, Florian M. E.
dc.contributor.authorvan Oostrum, Edgar
dc.contributor.authorTenke, Peter
dc.contributor.authorTandogdu, Zafer
dc.contributor.authorCek, Mete
dc.contributor.authorGrabe, Magnus
dc.contributor.authorWullt, Bjorn
dc.date.accessioned2024-06-12T11:12:58Z
dc.date.available2024-06-12T11:12:58Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Infection is a serious adverse effect of prostate biopsy (P-Bx), and recent reports suggest an increasing incidence. Objective: The aim of this multinational multicentre study was to evaluate prospectively the incidence of infective complications after P-Bx and identify risk factors. Design, setting, and participants: The study was performed as an adjunct to the Global Prevalence Study of Infections in Urology (GPIU) during 2010 and 2011. Men undergoing P-Bx in participating centres during the 2-wk period commencing on the GPIU study census day were eligible. Outcome measurements and statistical analysis: Baseline data were collected and men were questioned regarding infective complications at 2 wk following their biopsy. The Fisher exact test, Student t test, Mann-Whitney U test, and multivariate regression analysis were used for data analysis. Results and limitations: A total of 702 men from 84 GPIU participating centres worldwide were included. Antibiotic prophylaxis was administered prior to biopsy in 98.2% of men predominantly using a fluoroquinolone (92.5%). Outcome data were available for 521 men (74%). Symptomatic urinary tract infection (UTI) was seen in 27 men (5.2%), which was febrile in 18 (3.5%) and required hospitalisation in 16 (3.1%). Multivariate analysis did not identify any patient subgroups at a significantly higher risk of infection after P-Bx. Causative organisms were isolated in 10 cases (37%) with 6 resistant to fluoroquinolones. The small sample size per participating site and in compared with other studies may have limited the conclusions from our study. Conclusions: Infective complications after transrectal P-Bx are important because of the associated patient morbidity. Despite antibiotic prophylaxis, 5% of men will experience an infective complication, but none of the possible factors we examined appeared to increase this risk. Our study confirms a high incidence of fluoroquinolone resistance in causative bacteria. (C) 2012 European Association of Urology. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipEAUen_US
dc.description.sponsorshipThis study was organised by the board of the ESIU and endorsed and sponsored by the EAU and performed in collaboration with the Asian Association of UTI and STD, the International Society of Chemotherapy for Infection and Cancer, and the Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy.en_US
dc.identifier.doi10.1016/j.eururo.2012.06.003
dc.identifier.endpage527en_US
dc.identifier.issn0302-2838
dc.identifier.issn1873-7560
dc.identifier.issue3en_US
dc.identifier.pmid22704727en_US
dc.identifier.scopus2-s2.0-84872967763en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.1016/j.eururo.2012.06.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23378
dc.identifier.volume63en_US
dc.identifier.wosWOS:000314107100026en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProstate Biopsyen_US
dc.subjectInfective Complicationsen_US
dc.subjectUrinary Tract Infectionen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectUrinary-Tract-Infectionsen_US
dc.subjectEscherichia-Colien_US
dc.subjectAntibiotic-Prophylaxisen_US
dc.subjectRisk-Factorsen_US
dc.subjectResistanten_US
dc.subjectCiprofloxacinen_US
dc.subjectPathogensen_US
dc.titleInfective Complications After Prostate Biopsy: Outcome of the Global Prevalence Study of Infections in Urology (GPIU) 2010 and 2011, A Prospective Multinational Multicentre Prostate Biopsy Studyen_US
dc.typeArticleen_US

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