Might platelet-leucocyte complexes be playing a role in major vascular involvement of Behcet's disease? A comparative study

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dc.authorwosidCakir, Necati/AAG-7283-2019
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorPamuk, Guelsuem Emel
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorOrum, Hueseyin
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorTurgut, Burhan
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T10:54:21Z
dc.date.available2024-06-12T10:54:21Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe determined platelet-leucocyte complexes, which play roles in the thrombosis-inflammation relationship, in Behget's disease patients with and without major vascular involvement (MVI) and in healthy controls. We included 36 Behget's disease patients (22 male, 14 female, mean age: 34.4 +/- 8.3 years) and 20 healthy individuals (14 male, six female, mean age: 31.8 +/- 4.4 years). Whole blood count, CRIP and ESR were determined in both groups. Clinical data about the patients were obtained from medical charts. Individuals with hypertension, diabetes, coronary artery disease, and smokers were excluded. Behcet's disease patients with MVI were taken as a separate group (8 male, 5 female, mean age: 37 +/- 8 years). MVI was defined as the presence of pulmonary arterial aneurysm, deep venous thrombosis, vena cava inferior or superior thrombosis, or venous sinus thrombosis. Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Behget's disease patients with MVI had significantly higher PNC than Behcet's disease patients without MVI and healthy controls (P values=0.01). PMC levels in Behcet's disease patients with MVI were significantly higher than in healthy controls (P=0.01). The groups were similar in basal and ADP-stimulated platelet CD62P expression (P values >0.05). Basal and ADP-stimulated CD62P expression, PMC and PNC were not significantly different between active Behget's disease versus inactive Behget's disease patients. The evaluated parameters were similar in Behget's disease patients with and without uveitis, and pathergy-positive and pathergy-negative groups. Our results might suggest that the formation of PMC and PNC might play a role in thrombosis and MVI of Behget's disease. Blood Coagul Fibrinolysis 21:113-117 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MBC.0b013e328330bdc4
dc.identifier.endpage117en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue2en_US
dc.identifier.pmid20135752en_US
dc.identifier.scopus2-s2.0-76449102846en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e328330bdc4
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19011
dc.identifier.volume21en_US
dc.identifier.wosWOS:000274513600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's Diseaseen_US
dc.subjectPlatelet-Monocyte Complexesen_US
dc.subjectPlatelet-Neutrophil Complexesen_US
dc.subjectP-Selectin (CD62P)en_US
dc.subjectFlow-Cytometryen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectActivated Plateletsen_US
dc.subjectTissue Factoren_US
dc.subjectAdhesionen_US
dc.subjectNeutrophilen_US
dc.titleMight platelet-leucocyte complexes be playing a role in major vascular involvement of Behcet's disease? A comparative studyen_US
dc.typeArticleen_US

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