A case of granulomatosis with polyangiitis and pyoderma gangrenosum successfully treated with infliximab and rituximab

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dc.contributor.authorDonmez, Salim
dc.contributor.authorPamuk, Omer N.
dc.contributor.authorGedik, Mustafa
dc.contributor.authorAk, Recep
dc.contributor.authorBulut, Gulay
dc.date.accessioned2024-06-12T11:02:48Z
dc.date.available2024-06-12T11:02:48Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHere, we present a young male patient who was admitted with alveolar hemorrhage, arthritis and cutaneous lesions, who later developed bilateral orbital involvement and pyoderma gangrenosum (PG). He also had pathergy test positivity. The patient was refractory to conventional immunosuppressive therapy. Therefore, multiple devastating PG lesions and disease activity in granulomatosis with polyangiitis (GPA) were controlled with infliximab. Later, rituximab was used with success to prevent recurrence of symptoms. The relationship of PG with various autoimmune diseases is known; however, PG in GPA has been only rarely reported. Biologic agents might prove to be effective in GPA and PG patients who are refractory to standard immunosuppressive therapy.en_US
dc.identifier.doi10.1111/1756-185X.12274
dc.identifier.endpage475en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue4en_US
dc.identifier.pmid24460826en_US
dc.identifier.scopus2-s2.0-84901265902en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage471en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12274
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21416
dc.identifier.volume17en_US
dc.identifier.wosWOS:000337586300019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Rheumatic Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGranulomatous Polyangiitisen_US
dc.subjectPyoderma Gangrenosumen_US
dc.subjectRituximaben_US
dc.subjectTNF-Alpha Blockersen_US
dc.subjectWegeners-Granulomatosisen_US
dc.subjectMalignant Pyodermaen_US
dc.subjectTherapyen_US
dc.subjectPatienten_US
dc.titleA case of granulomatosis with polyangiitis and pyoderma gangrenosum successfully treated with infliximab and rituximaben_US
dc.typeArticleen_US

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