A new imaging modality in detection of caustic oesophageal injury: Technetium-99m pyrophosphate scintigraphy

dc.authoridTorun, Nese/0000-0002-5597-676X
dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidTorun, Nese/AAE-2718-2021
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorAksu, Burhan
dc.contributor.authorDurmus-Altun, Gulay
dc.contributor.authorUstun, Funda
dc.contributor.authorTorun, Nese
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUmit, Hasan
dc.contributor.authorSut, Nejdet
dc.date.accessioned2024-06-12T11:16:04Z
dc.date.available2024-06-12T11:16:04Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Early oesophagoscopy is usually recommended in children after caustic ingestion to assess the severity of the initial digestive lesions. An oesophagoscopic procedure in children always demands to be performed under sedation and bears a certain risk of iatrogenic injury. The purpose of the study is to determine the value and sensitivity of Tc-99m pyrophosphate (99mTc-PYP) scintigraphy for the detection of caustic oesophageal injury. Methods: The caustic oesophageal burns were created with 25% NaOH in an experimental rat model. Seventeen rats were divided into two groups. The BURN group (n = 9) included caustic oesophageal burning rats. Non-BURN group (n = 8) included sham-operated rats. All animals underwent 99mTc-PYP scintigraphy 72 In after the burning experiment. Anterior static and single-photon emission computed tomography images were obtained using a tow-energy all-purpose collimator, 2.55 zoom factor, 3 h after intravenous injection of 10 mCi 99mTc-PYP. After the imaging, all the oesophagi were explored for external determination of the injury sites and macroautoradiographic scintigraphy as well. Rectangular region of interest were placed in the visually determined lesion of oesophagus (0) as well as non-lesion area (N), and an ON ratio was created. The severity and extension of oesophageal burn were assessed 3 days after burning by histopathologic evaluation. The injuries were graded according to the ulcer depth, ulcer width, thrombus formation, and the development of perivascular fibrinoid necrosis. Results: The oesophageal burning areas were demonstrated by visual evaluation of the Tc-99m PYP scintigraphy on all animals. The mean ON ratio of 99mTc-PYP was 21.61 +/- 7.01 in the BURN group and in the non-BURN group, was 2.25 +/- 0.24 (p < 0.001). The best cut-off point of the ON ratio for caustic oesophageal injury was 5.45, with sensitivity and specificity of 100%. PYP scan findings were also confirmed by histological evidence of ulcer depth, ulcer width, thrombus formation, and perivascular fibrinoid necrosis in the same areas. Conclusions: The caustic oesophageal injuries have been demonstrated by 99mTc-PYP scintigraphy in burning experiment. 99mTc-PYP scintigraphy is sensitive for detection of caustic oesophageal injury. This new imaging tool is found to be sensitive and specific for the detection of caustic oesophageal injury in the rats. Published by Elsevier Ireland Ltd.en_US
dc.identifier.doi10.1016/j.ijporl.2008.11.008
dc.identifier.endpage415en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue3en_US
dc.identifier.pmid19124162en_US
dc.identifier.scopus2-s2.0-58649095709en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage409en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2008.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24182
dc.identifier.volume73en_US
dc.identifier.wosWOS:000263665400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTechnetium-99m Pyrophosphate Scintigraphyen_US
dc.subjectCausticen_US
dc.subjectOesophageal Injuryen_US
dc.subjectCorrosiveen_US
dc.subjectI-123-Bmippen_US
dc.subjectTc-99m-Pyrophosphateen_US
dc.subjectReperfusionen_US
dc.titleA new imaging modality in detection of caustic oesophageal injury: Technetium-99m pyrophosphate scintigraphyen_US
dc.typeArticleen_US

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