A comparative study of effects of tibolone, conjugated equine estrogen alone or combination with medroxyprogesterone acetate on plasma homocysteine levels in postmenopausal women

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dc.contributor.authorYüce, M. Ali
dc.contributor.authorKaplan, Balkanlı Petek
dc.contributor.authorGüçer, Fatih
dc.contributor.authorSayın, N. Cenk
dc.contributor.authorYüksel, Mahmut
dc.date.accessioned2024-06-12T10:18:13Z
dc.date.available2024-06-12T10:18:13Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: To assess the effect of estrogen, estrogen combined with progesterone or tibolon on serum total homocysteine levels, an independent risk factor for cardiovascular disorders, in postmenopausal women. STUDY DESIGN: In a randomised order, healthy, non-smoking postmenopausal women were included in the study. They received either conjugated equine estrogen 0.625 mg alone (CEE, n=16), CEE combined with medroxyprogesterone actate 5mg (CEE/MPA, n=20) or tibolon 2.5 mg (n=10). Treatments were given for three treatment cycles of 28 days (3 months). Plasma levels of homocysteine were measured at baseline and 3 months after the start of the study. RESULTS: There was no statistically significant change in plasma homocysteine levels in the only estrogen-treated group, sequentially combined CEE plus MPA-treated group and tibolone group. CONCLUCION: Neither CEE alone nor combination of CEE with MPA or tibolone treatment causes significant changes in plasma homocysteine levels in postmenopausal women with normal baseline homocysteine levels.en_US
dc.identifier.endpage193en_US
dc.identifier.issn1300-4751
dc.identifier.issn2602-4918
dc.identifier.issue3en_US
dc.identifier.startpage189en_US
dc.identifier.trdizinid61618en_US]
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/61618
dc.identifier.urihttps://hdl.handle.net/20.500.14551/15416
dc.identifier.volume11en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofGORM:Gynecology Obstetrics & Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleA comparative study of effects of tibolone, conjugated equine estrogen alone or combination with medroxyprogesterone acetate on plasma homocysteine levels in postmenopausal womenen_US
dc.typeArticleen_US

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