Dorsal sural nerve conduction study in vitamin B12 deficiency with megaloblastic anemia

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dc.authoridAKPINAR, SEVAL/0000-0002-6961-8971
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.authorwosidAKPINAR, SEVAL/HKD-9650-2023
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTurgut, Nilda
dc.contributor.authorAkpinar, Seval
dc.contributor.authorBalci, Kemal
dc.contributor.authorPamuk, Guelsuem E.
dc.contributor.authorTekguenduez, Emre
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-06-12T10:54:08Z
dc.date.available2024-06-12T10:54:08Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.descriptionInternational Meeting of the Peripheral-Nerve-Society -- FEB 06-JUN 08, 2006 -- Salt Lake City, UTen_US
dc.description.abstractPeripheral neuropathy is frequently observed in B-12 deficiency. In spite of this, there is little knowledge about peripheral neuropathy in B-12 deficiency because the severity of clinical involvement of the central nervous system clearly outweighs signs and symptoms due to peripheral nervous system involvement. We primarily investigated peripheral neuropathy with dorsal sural conduction study, which is a new method for detection of early peripheral neuropathy, in B-12 deficiency with megaloblastic anemia. Conventional nerve conduction studies and tibial sensory-evoked potential (SEP) recording were also performed. Twenty-eight B-12-deficient patients (15 male, 13 female, mean age 65.8 years) with megaloblastic anemia and 18 age- and sex-matched controls were included in the study. Although dorsal sural sensory nerve action potentials (SNAPs) were not recorded in 15 (54%) of 28 patients, only 9 (32%) of them were found to have polyneuropathy by conventional conduction studies. Furthermore, patients with dorsal sural SNAP had mean lower amplitude, mean longer latency, and slower velocity response when compared with controls. Twenty patients (71%) were diagnosed as having myelopathy by the combination of tibial SEP and neurological findings. Two patients whose dorsal sural SNAPs were not recorded had normal tibial SEP responses; therefore, these patients were considered to have isolated peripheral neuropathy. As a result, we conclude that dorsal sural nerve conduction study is a reliable method for detection of early peripheral neuropathy in B-12 deficiency.en_US
dc.description.sponsorshipPeripheral Nerve Socen_US
dc.identifier.doi10.1111/j.1529-8027.2006.00095.x
dc.identifier.endpage252en_US
dc.identifier.issn1085-9489
dc.identifier.issue3en_US
dc.identifier.pmid16930287en_US
dc.identifier.scopus2-s2.0-33747844549en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage247en_US
dc.identifier.urihttps://doi.org/10.1111/j.1529-8027.2006.00095.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18943
dc.identifier.volume11en_US
dc.identifier.wosWOS:000240005700007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofJournal Of The Peripheral Nervous Systemen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectB-12 Deficiencyen_US
dc.subjectDorsal Sural Nerveen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectSEPen_US
dc.subjectSubacute Combined Degenerationen_US
dc.subjectCobalamin-Deficiencyen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectClinical Utilityen_US
dc.subjectDiseaseen_US
dc.titleDorsal sural nerve conduction study in vitamin B12 deficiency with megaloblastic anemiaen_US
dc.typeConference Objecten_US

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