Investigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivo

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dc.authoridgoc rasgele, pınar/0000-0002-7558-3138
dc.authoridKAYA, Salih Tunc/0000-0002-4133-407X
dc.authoridGokalp, Fulya Dilek/0000-0001-8219-6657
dc.authorwosidKaya, Salih Tunc/B-6321-2015
dc.authorwosidgoc rasgele, pınar/S-8923-2016
dc.contributor.authorRasgele, Pinar Goc
dc.contributor.authorGokalp, Fulya Dilek
dc.contributor.authorKaya, Salih Tunc
dc.contributor.authorKekecoglu, Meral
dc.contributor.authorAcar, Merve Kambur
dc.date.accessioned2024-06-12T11:07:58Z
dc.date.available2024-06-12T11:07:58Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRhododendron honey (RH) is obtained from the rhododendron plants are grown in many regions around the world, causes poisoning in humans due to the grayanotoxin (GTX) compound in its structure. It is used by the public as a therapeutic for some diseases. It was aimed to study the genotoxic and cytotoxic effects of RH in mouse bone-marrow and sperm cells by using three mammalian bioassays. 25, 50 and 75 mg kg(-1) concentrations of RH given to male mice via gavage for 24 and 48 h treatment periods and its active ingredient Grayanatoxin (GTX-III) 0.01 mg kg(-1) by i.p. injection. Chromosome aberrations (CA), polychromatic erythrocytes (PCE)/normochromatic erythrocytes (NCE), micronucleated polychromatic erythrocytes (MNPCE) and sperm abnormalities were investigated. The results demonstrated that all the tested concentrations of RH significantly induced total abnormal cell frequency including chromosomal breaks for two time periods. In the MN assay, 75 mg kg(-1) RH and 0.01 mg kg(-1) GTX-III significantly increased % MNPCE and significantly reduced PCE/NCE ratios after 24 and 48 h treatments on mice demonstrating potential genotoxic and cytotoxic effect. Although there was a concentration-related increase in the percentage of total sperm abnormalities, this increase was not statistically significant compared to control. As a result, microscopic genotoxicity and cytotoxicity marker tests showed that RH and its active ingredient GTX-III have potential genotoxic and cytotoxic effect on mice bone marrow cells. It is understood that RH that is used to treat some diseases by public, should be handled carefully and used in a controlled manner.en_US
dc.description.sponsorshipDuzce University Scientific Research Fund [2013.01.01.199]en_US
dc.description.sponsorshipThis study was supported by Duzce University Scientific Research Fund [Project Number= 2013.01.01.199].en_US
dc.identifier.doi10.1080/01480545.2021.1935421
dc.identifier.endpage2310en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue5en_US
dc.identifier.pmid34100323en_US
dc.identifier.scopus2-s2.0-85107611857en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2301en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2021.1935421
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22261
dc.identifier.volume45en_US
dc.identifier.wosWOS:000658928300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMad Honeyen_US
dc.subjectGrayanatoxinen_US
dc.subjectChromosomal Aberrationen_US
dc.subjectMicronucleus Formationen_US
dc.subjectSperm Abnormalityen_US
dc.subjectMad Honeyen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectGrayanotoxin-Iiien_US
dc.subjectDamageen_US
dc.subjectAntioxidantsen_US
dc.subjectBradycardiaen_US
dc.subjectPlantsen_US
dc.titleInvestigation of genotoxic effects of rhododendron honey using three mammalian bioassays in vivoen_US
dc.typeArticleen_US

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