Elevated platelet-monocyte complexes in patients with psoriatic arthritis

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorPamuk, Guelsuem Emel
dc.contributor.authorPamuk, Oemer Nuri
dc.contributor.authorOrum, Hueseyin
dc.contributor.authorArican, Oezer
dc.contributor.authorTurgut, Burhan
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-06-12T11:13:05Z
dc.date.available2024-06-12T11:13:05Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe evaluated platelet and endothelial activation parameters in psoriatic arthritis (PsA), a disease reported to be associated with the development of endothelial dysfunction and increased atherosclerotic complications. Twenty patients with PsA, eight psoriasis and 20 healthy controls were included into the study. The patients' clinical features and acute phase parameters were assessed. In all patients and controls, platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), and basal and ADP-stimulated P-selectin expression were determined with flow cytometry; soluble E-selectin (sE-selectin) and soluble CD40L (sCD40L) were determined with ELISA. Patterns of joint involvement and degrees of skin involvement in PsA patients were assessed. PMC in PsA patients were significantly higher than in the control group (p = 0.02). PNC were not significantly different among the three groups (p values > 0.05). sE-selectin levels in both PsA and psoriasis groups were significantly higher than in healthy controls (p values, respectively, <0.001 and 0.023). Basal and ADP-stimulated CD62P expression and sCD40L level were similar in all groups (p values > 0.05). Polyarticular PsA patients had significantly higher sCD40L than oligoarticular plus spondylitic PsA groups (p = 0.04). sCD40L level was higher in active PsA group than in inactive PsA group (p = 0.03). Groups with limited and extensive skin involvement did not differ significantly in the evaluated parameters. C-reactive protein (CRP) level in PsA patients correlated with sCD40L (r = 0.69, p = 0.012), basal CD62P expression (r = 0.89, p < 0.001) and ADP-stimulated CD62P expression (r = 0.73, p = 0.001). Endothelial activation might be have a role in the pathogenesis of both psoriasis and PsA. Among parameters of platelet activation, only PMC might play a role in the pathogenesis of PsA.en_US
dc.identifier.doi10.3109/09537100903165174
dc.identifier.endpage497en_US
dc.identifier.issn0953-7104
dc.identifier.issue7en_US
dc.identifier.pmid19852688en_US
dc.identifier.scopus2-s2.0-70350506848en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage493en_US
dc.identifier.urihttps://doi.org/10.3109/09537100903165174
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23413
dc.identifier.volume20en_US
dc.identifier.wosWOS:000272718400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriatic Arthritisen_US
dc.subjectPsoriasisen_US
dc.subjectPlatelet-Monocyte Complexesen_US
dc.subjectCD40Len_US
dc.subjectE-Selectinen_US
dc.subjectInflammationen_US
dc.subjectAcute Myocardial-Infarction/en_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectCd40 Liganden_US
dc.subjectP-Selectinen_US
dc.subjectIncreased Expressionen_US
dc.subjectRisk-Factorsen_US
dc.subjectT-Cellsen_US
dc.subjectActivationen_US
dc.subjectCd154en_US
dc.subjectAtherosclerosisen_US
dc.titleElevated platelet-monocyte complexes in patients with psoriatic arthritisen_US
dc.typeArticleen_US

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