Serum soluble Fas ligand levels and peripheral blood lymphocyte subsets in patients with drug-induced maculopapular rashes, dress, and viral exanthemas

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dc.authorwosidYazicioglu, Mehtap/AAB-9587-2022
dc.contributor.authorYazicioglu, M.
dc.contributor.authorOzdemir, P. Gokmirza
dc.contributor.authorTurgut, B.
dc.contributor.authorSut, N.
dc.date.accessioned2024-06-12T10:59:53Z
dc.date.available2024-06-12T10:59:53Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Fatty acid synthetase (Fas)/Fas ligand (FasL)-dependent apoptotic pathways have been reported as being involved in the pathogenesis of drug-induced maculopapular rashes. Objective: We investigated serum soluble FasL (sFasL) levels and peripheral blood lymphocyte subtypes to discriminate maculopapular drug eruptions (MPDE) from viral exanthema (VE). Patients/methods: Children with confirmed MPDE (group I), VE (group II), and drug rashes with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) (group III) were included. Serum sFasL levels and peripheral blood lymphocyte subtypes were analyzed in groups I- III on admission, and repeated twice (only once for group IV-controls). Results: There were no significant serum soluble FasL level differences among the groups for all the samples. In the initial samples, CD19(+) cell numbers in group II were significantly higher than in group IV, and the CD4(+) /CD8(+) ratio was higher than groups I and IV. In the second samples, CD4(+) and CD19(+) cell numbers were significantly higher in group II than group I. In the final samples, CD4(+) cell numbers in group II were significantly higher than group I and group III. CD19(+) cells numbers in group III were significantly lower than the other groups for all samples. Conclusion: Serum sFasL levels were not found to be useful in discriminating viral exanthemas from other drug rashes. The significant differences between MPDE, VE, and DRESS were high CD4(+) and CD19(+) cell-count numbers in VE but low B-cell numbers in DRESS. This might be important for discriminating VE from DRESS, and the low B-cell count in early symptoms might be a useful predictor of DRESS development. (C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipResearch Council of Trakya University [TUBAP-2009/157]en_US
dc.description.sponsorshipThis study was supported by the Research Council of Trakya University (TUBAP-2009/157) (Edirne, Turkey).en_US
dc.identifier.doi10.1016/j.aller.2019.02.003
dc.identifier.endpage347en_US
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue4en_US
dc.identifier.pmid31375337en_US
dc.identifier.scopus2-s2.0-85069856242en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage339en_US
dc.identifier.urihttps://doi.org/10.1016/j.aller.2019.02.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20599
dc.identifier.volume48en_US
dc.identifier.wosWOS:000546977100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofAllergologia Et Immunopathologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrug-Induced Maculopapular Rashesen_US
dc.subjectDIHSen_US
dc.subjectDRESSen_US
dc.subjectViral Exanthemasen_US
dc.subjectSoluble Fas Liganden_US
dc.subjectLymphocyte Subpopulationsen_US
dc.subjectToxic Epidermal Necrolysisen_US
dc.subjectStevens-Johnson-Syndromeen_US
dc.subjectHuman-Herpesvirus-6 Reactivationen_US
dc.subjectAllergic Reactionsen_US
dc.subjectProvocation Testsen_US
dc.subjectDelayed-Reactionsen_US
dc.subjectAssociationen_US
dc.subjectDiagnosisen_US
dc.subjectCellsen_US
dc.titleSerum soluble Fas ligand levels and peripheral blood lymphocyte subsets in patients with drug-induced maculopapular rashes, dress, and viral exanthemasen_US
dc.typeArticleen_US

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