Early effects of low versus high dose atorvastatin treatment on coagulation and inflammation parameters in patients with acute coronary syndromes

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dc.contributor.authorOrdulu, Emine
dc.contributor.authorErdogan, Okan
dc.date.accessioned2024-06-12T11:15:38Z
dc.date.available2024-06-12T11:15:38Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: To demonstrate the efficacy of low or high dose statin treatment on C-reactive protein (CRP), von Willebrand Factor (vWF) and Factor VII (FVII) during the first two weeks of acute coronary syndromes. Patients and methods: Patients with acute coronary syndromes (n=60) were randomly and prospectively allocated in three different groups. They received 10 mg (low dose), 80 mg (high dose) of atorvastatin and placebo for two weeks. Plasma levels of CRP, vWF and FVII were compared at baseline, first and second weeks of treatment. Results: Low dose therapy resulted in non-significant elevation of CRP at first week, although high dose therapy significantly lowered its level (7.75 +/- 3.57 vs 7.13 +/- 2.95; p=.04). Both low and high dose therapies effectively suppressed the production and elevation of vWF in contrast to placebo (121.15 +/- 31.99 vs 139.7 +/- 28.53; p=.04). Conclusions: High dose atorvastatin significantly decreased CRP during the early days of acute coronary syndromes. Although vWF significantly increased in placebo group, both low and high dose atorvastatin treatments effectively suppressed its increased production. (c) 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2007.06.030
dc.identifier.endpage284en_US
dc.identifier.issn0167-5273
dc.identifier.issue2en_US
dc.identifier.pmid17655947en_US
dc.identifier.scopus2-s2.0-47749119560en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2007.06.030
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24002
dc.identifier.volume128en_US
dc.identifier.wosWOS:000257950500026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStatinen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectVwfen_US
dc.subjectCRPen_US
dc.subjectInflammationen_US
dc.subjectCoagulationen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectUnstable Anginaen_US
dc.subjectInstabilityen_US
dc.subjectEventsen_US
dc.subjectMiraclen_US
dc.titleEarly effects of low versus high dose atorvastatin treatment on coagulation and inflammation parameters in patients with acute coronary syndromesen_US
dc.typeLetteren_US

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