The protective effect of quercetin on IMA levels and apoptosis in experimental ovarian ischemia-reperfusion injury

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidHanci, Volkan/Q-1573-2019
dc.contributor.authorGencer, Meryem
dc.contributor.authorKaraca, Turan
dc.contributor.authorGungor, Ayse N. C.
dc.contributor.authorHacivehoglu, Servet O.
dc.contributor.authorDemirtas, Selim
dc.contributor.authorTurkon, Hakan
dc.contributor.authorUysal, Ahmet
dc.date.accessioned2024-06-12T11:13:20Z
dc.date.available2024-06-12T11:13:20Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To investigate the protective effect of quercetin (QE), an anti-inflammatory and anti-oxidant agent, on torsion-detorsion induced histopathological changes and blood IMA levels in experimental ovarian ischemia-reperfusion (IR) injury. Study design: Twenty-four female Wistar rats were randomly divided into four groups in this study (n = 6). Group I, (sham operation); Group II, torsion-detorsion plus saline (IR); Group III, torsiondetorsion plus solvent (dimethylsulfoxide: DMSO, IR + DMSO); Group IV, torsion-detorsion plus 15 mg/kg/bw quercetin (IR + QE) injected intraperitoneally 30 min prior to detorsion. After 3 h of reperfusion, the right ovaries were removed surgically. The ovary tissue samples were fixed in 10% formalin solution for histopathological and immunohistochemical examination. Blood samples were obtained at the end of the procedures for each group of animals. Results: Ovarian sections in Groups II and III showed higher follicular cell degeneration, hemorrhage, vascular congestion and edema when compared with Group I. Administration of quercetin in rats significantly prevented degenerative changes in the ovary. Significantly less histopathological changes were found in Group IV compared with Groups II and III. Caspase-3 and TUNEL positive cells were detected in the ovarian surface, follicle epithelium, and stromal cells in all experimental groups, and there was a significant increase in Groups II and III compared with Group I (P < 0.05). Treatment with quercetin decreased the number of caspase-3 and TUNEL positive cells. IR increased the ischemia modified albumin (IMA) levels in comparison to the sham group (1.06 +/- 0.10 ABSU and 0.92 +/- 0.08 ABSU, P < 0.05). Quercetin administration before IR reduced the levels of IMA (0.93 + 0.08 ABSU, P < 0.05). Conclusion: Administration of quercetin is effective in preventing tissue damage induced by IR injury in ovaries. (C) 2014 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejogrb.2014.03.036
dc.identifier.endpage140en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid24793929en_US
dc.identifier.scopus2-s2.0-84901040172en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2014.03.036
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23496
dc.identifier.volume177en_US
dc.identifier.wosWOS:000337863200026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectOvarian Torsionen_US
dc.subjectIschemia Modified Albuminen_US
dc.subjectApoptosisen_US
dc.subjectCaspase-3en_US
dc.subjectTUNELen_US
dc.subjectModified Albuminen_US
dc.subjectMyocardial-Ischemiaen_US
dc.subjectDimethyl-Sulfoxideen_US
dc.subjectTorsionen_US
dc.subjectMarkeren_US
dc.subjectDamageen_US
dc.subjectFlavonoidsen_US
dc.subjectBiomarkersen_US
dc.subjectSurgeryen_US
dc.subjectRaten_US
dc.titleThe protective effect of quercetin on IMA levels and apoptosis in experimental ovarian ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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