Investigation of the Protective Effects of Proanthocyanidin and Vitamin E against the Toxic Effect caused by Formaldehyde on the Liver Tissue

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dc.authoridUlucam, Enis/0000-0002-4686-7350
dc.authoridCerkezkayabekir, Aysegul/0000-0001-5537-1042;
dc.authorwosidUlucam, Enis/AAG-9204-2019
dc.authorwosidCerkezkayabekir, Aysegul/Q-6629-2018
dc.authorwosidUluçam, Enis/HQZ-3831-2023
dc.authorwosidBAKAR, Elvan/AAE-9247-2022
dc.contributor.authorBakar, Elvan
dc.contributor.authorUlucam, Enis
dc.contributor.authorCerkezkayabekir, Aysegul
dc.date.accessioned2024-06-12T11:12:54Z
dc.date.available2024-06-12T11:12:54Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe aimed to investigate of protective role of proanthocyanidin (PA) and vitamin E (vit E) against to toxic effect of formaldehyde (FA). Twenty-eight Wistar albino rats were divided into four groups: control group, rats treated with FA intraperitoneal (i.p.) (10 mg/kg), FA + vit E intragastric (i.g.) (30 mg/kg), and FA + PA i.g. (100 mg/kg). We assayed superoxide dismutase (SOD), glutathione peroxidase (Gpx), myeloperoxidase (MPO) activity and levels of malondialdehyde (MDA) and total sialic acid (TSA) in liver. Liver tissue was taken in order to morphological analysis and hepatocytes apoptosis using terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay immunostaining. SOD decreased in FA and increased in FA + vit E and FA + PA (p < 0.05). Gpx didn't change in FA and increased in FA + PA (p < 0.05). No significant variation between the groups was found in MPO activity. MDA increased only in FA and decreased in FA + vit E and FA + PA (p < 0.05). TSA didn't alter in FA and FA + vit E but decreased in FA + PA (p < 0.05). Degeneration in hepatocytes and endothelial cells, cytoplasm losses, vacuolization, picnotic nuclei, and mononuclear cell infiltration were identified in FA. Degeneration in chromatin material, membrane damage in mitochondria and losses in mitochondrial cristae in hepatocytes were observed in FA. We found that partially recovery in liver as a result of FA + vit E and FA + PA. We have concluded that long term use should be investigated for complete explanation of PA's protective effects on FA toxicity. (C) 2014 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/tox.22010
dc.identifier.endpage1415en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue12en_US
dc.identifier.pmid24930571en_US
dc.identifier.scopus2-s2.0-84947040781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1406en_US
dc.identifier.urihttps://doi.org/10.1002/tox.22010
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23351
dc.identifier.volume30en_US
dc.identifier.wosWOS:000364781900006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProanthocyanidinen_US
dc.subjectVitamin Een_US
dc.subjectFormaldehyde Toxicityen_US
dc.subjectOxidative Stressen_US
dc.subjectApoptosisen_US
dc.subjectLiveren_US
dc.subjectObstructive Pulmonary-Diseaseen_US
dc.subjectOxidative Damageen_US
dc.subjectIschemia/Reperfusion Injuryen_US
dc.subjectDiabetic-Nephropathyen_US
dc.subjectProcyanidin Extracten_US
dc.subjectLipid-Peroxidationen_US
dc.subjectFree-Radicalsen_US
dc.subjectRat-Kidneyen_US
dc.subjectAdult Ratsen_US
dc.subjectGrapeen_US
dc.titleInvestigation of the Protective Effects of Proanthocyanidin and Vitamin E against the Toxic Effect caused by Formaldehyde on the Liver Tissueen_US
dc.typeArticleen_US

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