Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.contributor.authorGuldiken, B.
dc.contributor.authorDemir, M.
dc.contributor.authorGuldiken, S.
dc.contributor.authorTurgut, N.
dc.contributor.authorOzkan, H.
dc.contributor.authorKabayel, L.
dc.contributor.authorTugrul, A.
dc.date.accessioned2024-06-12T10:52:44Z
dc.date.available2024-06-12T10:52:44Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNitric oxide (NO), which modulates endothelial function, is thought to be pivotal in the pathophysiology of migraines. The connection between migraine and cardiovascular diseases has also drawn attention to the endothelial dysfunctions and NO pathway abnormalities seen in patients with migraine. Our goal was to assess the levels of NO and the endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), in people with migraine during the interictal period. A total of 49 patients with migraine and 22 control subjects were enrolled in the study. Their plasma NO metabolites (nitrite [NO2-] and nitrate [NO3-]) and ADMA levels were measured using the enzyme-linked immunosorbent assay method, and were then compared with their cardiovascular risk factors, anthropometric measurements, and headache frequency and severity. The plasma ADMA, NO2 and NO3 levels of the patients with migraine during the interictal period did not differ from the control group, and no relationship was found between cardiovascular risk factors and migraine attack severity and frequency. We conclude that, in patients with migraine, there is no dysfunction of baseline NO and ADMA metabolism during the interictal period. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocn.2008.08.015
dc.identifier.endpage674en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.issue5en_US
dc.identifier.pmid19282179en_US
dc.identifier.scopus2-s2.0-62549115292en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage672en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2008.08.015
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18805
dc.identifier.volume16en_US
dc.identifier.wosWOS:000265223900013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectMigraineen_US
dc.subjectNitric Oxideen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectPlasma-Levelsen_US
dc.subjectSynthaseen_US
dc.subjectRisken_US
dc.subjectAdmaen_US
dc.subjectStrokeen_US
dc.subjectInhibitoren_US
dc.subjectPlateletsen_US
dc.subjectHeadacheen_US
dc.subjectPathwayen_US
dc.titleAsymmetric dimethylarginine and nitric oxide levels in migraine during the interictal perioden_US
dc.typeArticleen_US

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