The Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patients

Basit Öğe Kaydı
dc.authoriddemir, melik/0000-0003-1711-6707
dc.authoridKorkmaz, Selçuk/0000-0003-4632-6850
dc.authoridKaya, Caglar/0000-0002-2968-5352
dc.authoridZEYBEY, UTKU/0000-0003-3997-0517
dc.authoridGURDOGAN, Muhammet/0000-0001-5650-9066
dc.authoridAltay, Servet/0000-0001-7112-3970
dc.authoridEBIK, MUSTAFA/0000-0002-0585-0958
dc.authorwosiddemir, melik/AAC-1081-2022
dc.authorwosidKorkmaz, Selçuk/AAU-4677-2020
dc.authorwosidKaya, Caglar/GSN-9700-2022
dc.authorwosidDemir, Melik/HGE-0608-2022
dc.authorwosidAltay, Servet/C-1387-2018
dc.contributor.authorGurdogan, Muhammet
dc.contributor.authorAltay, Servet
dc.contributor.authorKorkmaz, Selcuk
dc.contributor.authorKaya, Caglar
dc.contributor.authorZeybey, Utku
dc.contributor.authorEbik, Mustafa
dc.contributor.authorDemir, Melik
dc.date.accessioned2024-06-12T10:50:32Z
dc.date.available2024-06-12T10:50:32Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objectives: Despite being within the normal reference range, changes in thyroid stimulating hormone (TSH) levels have negative effects on the cardiovascular system. The majority of patients admitted to hospital with acute coronary syndrome (ACS) are euthyroid. The aim of this study was to investigate the effect of TSH level on the prognosis of in-hospital and follow-up periods of euthyroid ACS patients. Materials and Methods: A total of 629 patients with acute coronary syndrome without thyroid dysfunction were included in the study. TSH levels of patients were 0.3-5.33 uIU/mL. Patients were divided into three TSH tertiles: TSH level between (1) 0.3 uIU/mL and <0.90 uIU/mL (n = 209), (2) 0.90 uIU/mL and <1.60 uIU/mL (n = 210), and (3) 1.60 uIU/mL and 5.33 uIU/mL (n = 210). Demographic, clinical laboratory, and angiographic characteristics were compared between groups in terms of in-hospital and follow-up prognosis. Results: Mean age was 63.42 +/- 12.5, and 73.9% were male. There was significant difference between tertiles in terms of TSH level at admission (p < 0.001), the severity of coronary artery disease (p = 0.024), in-hospital mortality (p < 0.001), in-hospital major hemorrhage (p = 0.005), total adverse clinical event (p = 0.03), follow-up mortality (p = 0.022), and total mortality (p < 0.001). In multivariate logistic regression analysis, the high-normal TSH tertile was found to be cumulative mortality increasing factor (OR = 6.307, 95%; CI: 1.769-22.480; p = 0.005) during the 6-month follow-up period after hospitalization and discharge. Conclusions: High-normal TSH tertile during hospital admission in euthyroid ACS patients is an independent predictor of total mortality during the 6-month follow-up period after hospitalization and discharge.en_US
dc.identifier.doi10.3390/medicina55050175
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue5en_US
dc.identifier.pmid31137601en_US
dc.identifier.scopus2-s2.0-85067013280en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina55050175
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18043
dc.identifier.volume55en_US
dc.identifier.wosWOS:000472666200060en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectThyroid-Stimulating Hormoneen_US
dc.subjectMortalityen_US
dc.subjectPrognosisen_US
dc.subjectHeart-Diseaseen_US
dc.subjectSubclinical Hypothyroidismen_US
dc.subjectAll-Causeen_US
dc.subjectRisken_US
dc.subjectTshen_US
dc.subjectDysfunctionen_US
dc.subjectMortalityen_US
dc.subjectInflammationen_US
dc.subjectAssociationen_US
dc.subjectActivationen_US
dc.titleThe Effect of Thyroid Stimulating Hormone Level Within the Reference Range on In-Hospital and Short-Term Prognosis in Acute Coronary Syndrome Patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu