The levels of circulating markers of atherosclerosis and inflammation in subjects with different degrees of body mass index: Soluble CD40 ligand and high-sensitivity C-reactive protein

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorArikan, Ender
dc.contributor.authorTurgut, Burhan
dc.contributor.authorAzcan, Sennur
dc.contributor.authorGerenli, Murat
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: It is welt demonstrated that obesity is an independent risk factor for cardiovascular diseases. Recent studies have shown that obesity, insulin resistance and atherosclerosis are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown that CD40-soluble CD40 ligand (sCD40L) interactions might constitute an important mediator for vascular inflammation. The aim of the present study was to assess sCD40L in relation to hs-CRP and cardiovascular risk factors in relation to body mass index (BMI). Materials and methods: Serum sCD40L and hs-CRP concentrations were measured in 52 obese patients and 28 non-obese subjects by ELISA. Insulin resistance was calculated by homeostasis model assessment-insulin resistance (HOMA-IR). We divided the participants into three groups depending in their BMI levels (Group 1: BMI < 25 kg/m(2), Group 2: BMI 30-34.9 kg/m(2), Group 3: BMI >= 35 kg/m(2)). Results: We determined that the mean sCD40L of group 3 was significantly higher than group 1 and group 2 (p < 0.05, p < 0.05, respectively). However, there was no significant correlation between plasma sCD40L levels and BMI. Plasma levels of hs-CRP were higher in obese group than the non-obese group (p < 0.001). The Levels of sCD40L were not significantly different between the two groups. The mean hs-CRP levels increased gradually in accordance with groups of BMI, there was a strong correlation between hs-CRP levels and BMI (r = 0.724, p < 0.001). There was no significant correlation between sCD40L and hs-CRP levels in all participants. Conclusions: It is still a subject for debate whether sCD40L Levels are increased or not in obesity. However, the results of this study showed that sCD40L is substantially increased in patients with severe obesity. In terms of causality, the relatively small sample size and cross-sectional design of this study are considered to be the limitation factors. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.thromres.2005.12.019
dc.identifier.endpage84en_US
dc.identifier.issn0049-3848
dc.identifier.issn1879-2472
dc.identifier.issue1en_US
dc.identifier.pmid16476470en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2005.12.019
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22826
dc.identifier.volume119en_US
dc.identifier.wosWOS:000242682400010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofThrombosis Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectAtherosclerosisen_US
dc.subjectInflammationen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectScd40len_US
dc.subjectInsulin-Resistanceen_US
dc.subjectCardiovascular Risken_US
dc.subjectObesityen_US
dc.subjectInterleukin-6en_US
dc.subjectAssociationsen_US
dc.subjectActivationen_US
dc.subjectExpressionen_US
dc.subjectHealthyen_US
dc.subjectDiseaseen_US
dc.titleThe levels of circulating markers of atherosclerosis and inflammation in subjects with different degrees of body mass index: Soluble CD40 ligand and high-sensitivity C-reactive proteinen_US
dc.typeArticleen_US

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