Recommendations for Clinical Decision-making in Children with Type 1 Diabetes and Celiac Disease: Type 1 Diabetes and Celiac Disease Joint Working Group Report

Basit Öğe Kaydı
dc.authoridDoğan, Yaşar/0000-0001-9738-9611
dc.authoridTaskin, Orhun/0000-0002-6668-3006
dc.authoridEliuz Tipici, Beyza/0000-0002-9790-7340
dc.authoridBas, Firdevs/0000-0001-9689-4464
dc.authoridERTEM, DENIZ/0000-0002-4427-0569
dc.authoridTaskin, Orhun/0000-0002-6668-3006
dc.authoridMutlu, Gul Yesiltepe/0000-0003-3919-7763;
dc.authorwosidDoğan, Yaşar/V-7962-2018
dc.authorwosidTaskin, Orhun/CAI-7603-2022
dc.authorwosidEliuz Tipici, Beyza/HSF-0679-2023
dc.authorwosidBas, Firdevs/AAF-6511-2020
dc.authorwosidERTEM, DENIZ/C-2285-2015
dc.authorwosidEvliyaoglu, Olcay/D-6483-2019
dc.authorwosidTaskin, Orhun/CAG-0880-2022
dc.contributor.authorHatun, Sukru
dc.contributor.authorDalgic, Buket
dc.contributor.authorGoksen, Damla
dc.contributor.authorAydogdu, Sema
dc.contributor.authorErdeve, Senay Savas
dc.contributor.authorKulogu, Zarife
dc.contributor.authorDogan, Yasar
dc.date.accessioned2024-06-12T10:56:18Z
dc.date.available2024-06-12T10:56:18Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt is well-known that in children with type 1 diabetes (T1D), the frequency of Celiac disease (CD) is increased due to mechanisms which are not fully elucidated but include autoimmune injury as well as shared genetic predisposition. Although histopathologic examination is the gold standard for diagnosis, avoiding unnecessary endoscopy is crucial. Therefore, for both clinicians and patients' families, the diagnosis of CD remains challenging. In light of this, a joint working group, the Type 1 Diabetes and Celiac Disease Joint Working Group, was convened, with the aim of reporting institutional data and reviewing current international guidelines, in order to provide a framework for clinicians. Several controversial issues were discussed: For CD screening in children with T1D, regardless of age, it is recommended to measure tissue transglutaminase-immunoglobulin A (tTG-IgA) and/or endomysial-IgA antibody due to their high sensitivity and specificity. However, the decision-making process based on tTG-IgA titer in children with T1D is still debated, since tTGIgA titers may fluctuate in children with T1D. Moreover, seronegativity may occur spontaneously. The authors' own data showed that most of the cases who have biopsy-proven CD had tTG-IgA levels 7-10 times above the upper limit. The decision for endoscopy based solely on tTG-IgA levels should be avoided, except in cases where tTG-IgA levels are seven times and above the upper limit. A closer collaboration should be built between divisions of pediatric endocrinology and gastroenterology in terms of screening, diagnosis and follow-up of children with T1D and suspicious CD.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2021.2021.0139
dc.identifier.endpage9en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue1en_US
dc.identifier.pmid34538045en_US
dc.identifier.scopus2-s2.0-85125682634en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2021.2021.0139
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19747
dc.identifier.volume14en_US
dc.identifier.wosWOS:000778594700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal Of Clinical Research In Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectType 1 Diabetesen_US
dc.subjectCeliac Diseaseen_US
dc.subjectAnti-Tissue Transglutaminase-Igaen_US
dc.subjectTurkish Childrenen_US
dc.subjectGlycemic Indexen_US
dc.subjectPrevalenceen_US
dc.subjectGlutenen_US
dc.subjectAdolescentsen_US
dc.subjectManagementen_US
dc.subjectDiagnosisen_US
dc.subjectProteinen_US
dc.titleRecommendations for Clinical Decision-making in Children with Type 1 Diabetes and Celiac Disease: Type 1 Diabetes and Celiac Disease Joint Working Group Reporten_US
dc.typeReview Articleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu