Effect of Ginkgo biloba extract (EGb 761) on the healing of left colonic anastomoses in rat

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dc.authoridKösem, Mustafa/0000-0002-2347-0940
dc.authoridOzdemir, Hulya/0000-0002-6045-8342
dc.authorwosidKösem, Mustafa/JCE-7269-2023
dc.contributor.authorKisli, Erol
dc.contributor.authorOzdemir, Huelya
dc.contributor.authorKosem, Mustafa
dc.contributor.authorSurer, Hatice
dc.contributor.authorCiftci, Ali
dc.contributor.authorKanter, Mehmet
dc.date.accessioned2024-06-12T11:17:35Z
dc.date.available2024-06-12T11:17:35Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground The aim of this study was to assess the effect of Ginkgo biloba extract (EGb 761) on healing of experimental colonic anastomoses in a rat model. Methods Rats were divided into four groups: postoperative day (POD) 3 untreated control group, POD 3 EGb 761 group, POD 7 untreated control group, and POD 7 EGb 761 group. In the oral EGb 761 groups, the agent was given at 9.6 mg daily per orogastric route using a 4-F fine feeding catheter. We measured bursting pressures and hydroxyproline content and histologically examined the resected anastomoses on POD 3 and POD 7. Results The bursting pressures increased more in the EGb 761 group than in the untreated control group on POD 3, but this difference was not statistically significant. Hydroxyproline content was higher in the EGb 761 group than in the untreated control group on POD 3, and this difference was statistically significant. Anastomosis bursting pressure values and hydroxyproline contents were significantly higher in the EGb 761 group than in the untreated control group on POD 7. Histological examination showed greater fibroblastic activity in the EGb 761 group than in the untreated control group on POD 3. There was no significant difference in anastomotic polimorphonuclear leukocyte, mononuclear cells and blood vessel neodevelopment between the POD 3 groups, but there was significant difference in fibroblastic activity and blood vessel neodevelopment between the POD 7 groups. Conclusions These results showed us that EGb 761 administration resulted in enhanced stability of colonic anastomoses during the first postoperative week.en_US
dc.identifier.doi10.1007/s00268-007-9049-8
dc.identifier.endpage1657en_US
dc.identifier.issn0364-2313
dc.identifier.issn1432-2323
dc.identifier.issue8en_US
dc.identifier.pmid17578646en_US
dc.identifier.scopus2-s2.0-34447327277en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1652en_US
dc.identifier.urihttps://doi.org/10.1007/s00268-007-9049-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24767
dc.identifier.volume31en_US
dc.identifier.wosWOS:000248060600018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofWorld Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnterior Resectionen_US
dc.subjectHemorrhageen_US
dc.subjectPhenytoinen_US
dc.subjectLeakageen_US
dc.titleEffect of Ginkgo biloba extract (EGb 761) on the healing of left colonic anastomoses in raten_US
dc.typeArticleen_US

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