Value of MRI apparent diffusion coefficient for assessment of response to sorafenib in hepatocellular carcinoma

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dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridKöstek, Osman/0000-0002-1901-5603
dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.contributor.authorKostek, Osman
dc.contributor.authorYilmaz, Erdem
dc.contributor.authorHacioglu, Muhammet Bekir
dc.contributor.authorErdogan, Bulent
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorBekmez, Esma Turkmen
dc.contributor.authorHacibekiroglu, Ilhan
dc.date.accessioned2024-06-12T10:50:39Z
dc.date.available2024-06-12T10:50:39Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Efficient and adequate evaluation of therapeutic response in hepatocellular carcinoma (HCC) is an evolving field. We aimed to evaluate apparent diffusion coefficient (ADC) values in the prediction of response to sorafenib and prognosis in patients with advanced HCC. Methods: Baseline magnetic resonance (MR) imaging was performed before treatment. After sorafenib started, clinical and radiological response were evaluated at approximately 3 months later. ADC measurements were performed by a 12year experienced radiologist who evaluated MR before and after sorafenib therapy. Results: A total of 17 patients (median age 60 years, range 51-66 and M/F ratio= 3.25/1) were analyzed. A significant increase in ADC levels in responders was observed 3 months after sorafenib therapy. Baseline and post-sorafenib ADC values were not significantly associated with mortality (hazard ratio/HR baseline ADC = 1.003, p = 0.98) and after sorafenib (HR 0.480, p = 0.48, respectively). Conclusion: Advanced HCC patients with a favorable response to sorafenib had a significant increase in ADC value at the first radiological evaluation. The predictive and prognostic role of ADC for overall survival is still unknown and further research is needed to investigate any possible association.en_US
dc.identifier.endpage984en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue4en_US
dc.identifier.pmid30358202en_US
dc.identifier.scopus2-s2.0-85054936486en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage979en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18081
dc.identifier.volume23en_US
dc.identifier.wosWOS:000441820800018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal Of Buonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADCen_US
dc.subjectHCCen_US
dc.subjectMonitoring Responseen_US
dc.subjectSorafeniben_US
dc.subjectModified Recist Mrecisten_US
dc.subjectWeighted Mrien_US
dc.subjectModelen_US
dc.titleValue of MRI apparent diffusion coefficient for assessment of response to sorafenib in hepatocellular carcinomaen_US
dc.typeArticleen_US

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