The Relationship Between Factor VIII and Coronary Artery Diseases

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dc.authoridAlp Kirkizlar, Tugcan/0000-0002-1361-6213
dc.authoridHassoy, Hür/0000-0001-7180-395X
dc.authoridSAYILAN, SAMET/0000-0002-8959-8381
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridAcar, Şencan/0000-0001-8086-0956
dc.authoridMERAL, CENK EMRE/0000-0003-4091-626X
dc.authorwosidAlp Kirkizlar, Tugcan/AAI-5246-2020
dc.authorwosidHassoy, Hür/ABB-4173-2020
dc.authorwosidSAYILAN, SAMET/JJC-7452-2023
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidAlp Kirkizlar, Tugcan/HMD-4249-2023
dc.authorwosidAcar, Şencan/ACK-5013-2022
dc.authorwosidKaraali, Zeynep/AAL-4410-2020
dc.contributor.authorMeral, Cenk Emre
dc.contributor.authorAktuglu, Mehmet Burak
dc.contributor.authorHassoy, Hur
dc.contributor.authorKaraali, Zeynep
dc.contributor.authorAlioglu, Taner
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorAcar, Sencan
dc.date.accessioned2024-06-12T11:01:34Z
dc.date.available2024-06-12T11:01:34Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Cardiovascular diseases are the major cause of morbidity and mortality worldwide. There are some evidences showing a possible role for hemotostatic system in the pathogenesis of atherosclerotic vascular diseases. In our study, we aimed to show the relationship between coronary artery diseases and factor VIII (F VIII). Methods: 60 patients were included in the study. Blood samples for F VIII were taken before and after the standard Bruce treadmill stress test. Patients with positive stress test underwent coronary angiography. Results: The F VIII levels after the treadmill test were statistically significantly high (p: 0.0001) compared to that before the test. A significant difference was determined in favor of female patients both before (p= 0.002) and after (p= 0.009) the treadmill exercise test when F VIII levels were assessed by gender. Conclusion: Since the discovery of the important role of thrombosis in the pathogenesis of atherosclerotic diseases, investigators are working on whether the haemostatic status is the primary risk factor in coronary artery disease (CAD). Our study results, similar to the literature, showed that F VIII levels in women can be helpful in the diagnosis and follow-up of CAD. But as shown in other studies, F VIII levels may increase in an inflammatory state. Therefore, further studies are needed to determine whether CAD is caused by high levels of F VIII or risk factors for CAD cause endothelial damage and, thus, high levels of F VIII are the result of an inflammatory process.en_US
dc.identifier.doi10.4274/Haseki.726
dc.identifier.endpage118en_US
dc.identifier.issn1302-0072
dc.identifier.issn2147-2688
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84871573379en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.4274/Haseki.726
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20949
dc.identifier.volume50en_US
dc.identifier.wosWOS:000216734400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofHaseki Tip Bulteni-Medical Bulletin Of Hasekien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExercise Testen_US
dc.subjectCoronary Artery Diseaseen_US
dc.subjectFactor VIIIen_US
dc.titleThe Relationship Between Factor VIII and Coronary Artery Diseasesen_US
dc.typeArticleen_US

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