Fibroblast Growth Factor-23 and Carotid Artery Intima Media Thickness in Chronic Kidney Disease

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dc.authoridsevinc, can/0000-0002-4069-9181
dc.authorwosidYilmaz, Gulay/AAP-1142-2020
dc.contributor.authorYilmaz, Gulay
dc.contributor.authorUstundag, Sedat
dc.contributor.authorTemizoz, Osman
dc.contributor.authorSut, Necdet
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorErmis, Veli
dc.contributor.authorSevinc, Can
dc.date.accessioned2024-06-12T10:52:46Z
dc.date.available2024-06-12T10:52:46Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The cause of early-accelerated atherosclerosis development observed in Chronic Kidney Disease (CKD) is not fully understood. The determination of the relationship between the levels of fibroblast growth factor 23 (FGF-23) and the development of endothelial dysfunction, left ventricular hypertrophy, and myocardial infarction lends support to the possibility that FGF-23 plays a role in the development of atherosclerosis in CKD. Only a few studies, however, have been conducted that analyze the relationship between FGF-23 levels in the progression of CKD and the development of atherosclerosis, and these studies have generally been limited to those patients receiving dialysis therapy due to end stage renal disease (ESRD). Methods: In the present study, carotid artery intima-media thicknesses (IMT) were measured ultrasonically as a marker of atherosclerosis in 91 patients with CKD stage 3 - 4 (61 female and 30 male, age between 19 - 65 years, glomerular filtration rate [GFR] 15 - 60 mL/min 1.73 m(2), CKD was not related to diabetes mellitus, and without cardiovascular-cerebral disease) in contrast to 36 healthy volunteers (26 female and 10 male, age between 19 - 65 years, GFR > 90 mL/min 1.73 m(2), and without any diagnoses of acute or chronic disease), and a possible role of FGF-23 on atherosclerosis was analyzed. Results: Patients were similar to controls with respect to age, gender, smoking status, body mass index, and plasma glucose and lipid profile. On the other hand, IMT measurements (p < 0.00001) and FGF-23 levels (p = 0.00012) were significantly higher in patients than controls. IMT was measured above the subclinical atherosclerosis limit of 0.750 mm in 54% of the patients. Multivariate regression analysis showed that patients' age, high sensitive c-reactive protein (hsCRP), and FGF-23 levels were independent predictors of IMT (p < 0.00001, r = 0.559). Independent of other variables, every 1 mu mol/L increase in FGF-23 levels resulted in 0.444 mm increase of IMT measurements in patients with CKD. Conclusions: Our findings suggest that monitoring serum FGF-23 may be useful as a non-invasive indicator of subclinical atherosclerosis in patients with chronic kidney disease.en_US
dc.identifier.doi10.7754/Clin.Lab.2015.141236
dc.identifier.endpage1070en_US
dc.identifier.issn1433-6510
dc.identifier.issue8en_US
dc.identifier.pmid26427152en_US
dc.identifier.scopus2-s2.0-84941617181en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1061en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2015.141236
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18827
dc.identifier.volume61en_US
dc.identifier.wosWOS:000359956000023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectFibroblast Growth Factor 23en_US
dc.subjectIntima Media Thicknessen_US
dc.subjectLeft-Ventricular Hypertrophyen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectHemodialysis-Patientsen_US
dc.subjectDialysis Patientsen_US
dc.subjectMortality Risken_US
dc.subjectFgf23en_US
dc.subjectCalcificationen_US
dc.subjectProgressionen_US
dc.subjectPhosphorusen_US
dc.subjectCalciumen_US
dc.titleFibroblast Growth Factor-23 and Carotid Artery Intima Media Thickness in Chronic Kidney Diseaseen_US
dc.typeArticleen_US

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