The impact of trastuzumab on radiation-induced pulmonary fibrosis: results of an experimental study

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dc.authoridKepil, Nuray/0000-0001-5494-6422;
dc.authorwosidKepil, Nuray/AAH-7959-2019
dc.authorwosidUmay, Cenk/ABI-2899-2020
dc.contributor.authorBese, N. S.
dc.contributor.authorUmay, C.
dc.contributor.authorSerdengecti, S.
dc.contributor.authorKepil, N.
dc.contributor.authorSut, N.
dc.contributor.authorAltug, T.
dc.contributor.authorOber, A.
dc.date.accessioned2024-06-12T11:16:41Z
dc.date.available2024-06-12T11:16:41Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description6th European Breast Cancer Conference -- APR 15-19, 2008 -- Berlin, GERMANYen_US
dc.description.abstractThere are no data regarding the late toxicity of trastuzumab (T) administration with radiotherapy (RT). In this experimental study, we aimed to asses if concurrent or sequential administration of T has any impact for the development of radiation-induced pulmonary fibrosis in rats. Fifty-four female Wistar-albino rats were divided into 6 groups. First group of rats (Group 1; concurrent T) had irradiation to whole thoracic region concurrently with T. Second group (Group 2: sequential T-RT) received thoracic irradiation, 1 week after T. Third group (Group 3: sequential RT-T) had thoracic irradiation first and they had T injection 1 week after RT. Fourth group (Group 4: T only) had only T application. Fifth group (Group 5: RT) had only RT. The last group (Group 6: sham) of rats were observed without any application. A single dose of 12 Gy was given to both lungs with an anterior field at 2 cm depth. T dose which was equivalent to 6 mg/kg adult dose was calculated for each rat, and injected by the tail vein. As an end point the extent of pulmonary fibrosis for each field was graded on a scale from 0 (normal lung or minimal fibrous thickening) to 4 (total fibrous obliteration of the field) at histopathological examination. The mean value of fibrosis scores were 1.44, 1.77, 1.75 and 1.62 for Group 1, 2, 3 and 5, respectively, without any statistically significant differences among them (P > 0.05). The mean value of fibrosis scores for Group 4 and 6 were 0.25 and 0.33, respectively (P > 0.05). When the mean value of fibrosis scores of the groups which had RT with or without T, compared with the observation and the T only groups, the difference was significant (P < 0.05) (one-way ANOVA and Tukey HSD post hoc tests) As a conclusion: addition of T to thoracic irradiation either sequentially or concomitantly did not increase radiation-induced pulmonary fibrosis in rats.en_US
dc.identifier.doi10.1007/s12032-009-9395-5
dc.identifier.endpage1419en_US
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue4en_US
dc.identifier.pmid20041318en_US
dc.identifier.scopus2-s2.0-79951770565en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1415en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-009-9395-5
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24391
dc.identifier.volume27en_US
dc.identifier.wosWOS:000284547800061en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrastuzumaben_US
dc.subjectRadiation Therapyen_US
dc.subjectLate Toxicityen_US
dc.subjectHer2-Positive Breast-Canceren_US
dc.subjectConcurrent Trastuzumaben_US
dc.subjectAdjuvant Chemotherapyen_US
dc.subjectMonoclonal-Antibodyen_US
dc.subjectFollow-Upen_US
dc.subjectRadiotherapyen_US
dc.subjectPlusen_US
dc.subjectIrradiationen_US
dc.subjectToxicityen_US
dc.titleThe impact of trastuzumab on radiation-induced pulmonary fibrosis: results of an experimental studyen_US
dc.typeConference Objecten_US

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