A Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediators

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dc.authoridOrhan, Cemal/0000-0003-4138-7689
dc.authoridYabas, Mehmet/0000-0002-3462-5389
dc.authoridEr, Besir/0000-0002-9583-2218
dc.authoridÖZERCAN, ibrahim Hanifi/0000-0002-8781-8838
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridDURMUS, Ali Said/0000-0003-4873-5690
dc.authoridTuzcu, Mehmet/0000-0002-1329-3143
dc.authorwosidOrhan, Cemal/Q-2086-2015
dc.authorwosidDURMUŞ, Ali Said/V-8573-2018
dc.authorwosidYabas, Mehmet/D-9513-2012
dc.authorwosidEr, Besir/GXV-6448-2022
dc.authorwosidÖZERCAN, ibrahim Hanifi/W-7883-2018
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidTuzcu, Mehmet/H-2953-2018
dc.contributor.authorYabas, Mehmet
dc.contributor.authorOrhan, Cemal
dc.contributor.authorEr, Besir
dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorDurmus, Ali Said
dc.contributor.authorOzercan, Ibrahim Hanifi
dc.contributor.authorSahin, Nurhan
dc.date.accessioned2024-06-12T10:51:59Z
dc.date.available2024-06-12T10:51:59Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOsteoarthritis (OA) is a chronic and debilitating disease of the knee joint. OA of the knee is initiated by physical damage and accumulated oxidative stress, followed by an exaggerated inflammation leading to cartilage damage. Currently, no effective and safe therapeutic option capable of restoring articular cartilage tissue and joint architecture is available. We here report a novel and highly bioavailable formulation of curcumin, labeled as Next Generation Ultrasol Curcumin (NGUC), which was 64.7 times more bioavailable than natural 95% curcumin extract as demonstrated in rat bioavailability studies. We further investigated the protective effect of NGUC against monosodium iodoacetate (MIA)-induced knee OA in rats. Analysis of X-ray and histopathological images revealed that NGUC supplementation restored joint architecture and reduced swelling of joints induced by MIA. NGUC treatment caused a significant reduction in the levels of inflammatory mediators such as TNF-alpha, IL-1 beta, IL-6, COMP, and CRP, and expressions of MMP-3, 5-LOX, COX-2, and NF kappa B in synovial tissue of rats with MIA-induced OA. NGUC also decreased serum MDA level and increased the levels of antioxidant enzymes SOD, CAT, and GPX. Thus, our results indicate that a novel formulation of curcumin with enhanced bioavailability effectively ameliorates the pathophysiology of OA.en_US
dc.description.sponsorshipOmniActive Health Technologies; TUBITAKen_US
dc.description.sponsorshipOmniActive Health Technologies and TUBITAK (KS). The funders had no role in the project design, data collection, data analyses and interpretation.en_US
dc.identifier.doi10.3389/fimmu.2021.609629
dc.identifier.issn1664-3224
dc.identifier.pmid33776996en_US
dc.identifier.scopus2-s2.0-85103096004en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fimmu.2021.609629
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18562
dc.identifier.volume12en_US
dc.identifier.wosWOS:000632633700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectCurcuminen_US
dc.subjectImmunomodulationen_US
dc.subjectInflammationen_US
dc.subjectInflammatory Diseasesen_US
dc.subjectOsteoarthritisen_US
dc.subjectOsteoimmunologyen_US
dc.titleA Next Generation Formulation of Curcumin Ameliorates Experimentally Induced Osteoarthritis in Rats via Regulation of Inflammatory Mediatorsen_US
dc.typeArticleen_US

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