REVERSIBLE HEPATOCEREBRAL DEGENERATION-LIKE SYNDROME DUE TO PORTOVENOUS SHUNTS

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dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.contributor.authorGuler, Sibel
dc.contributor.authorUtku, Ufuk
dc.contributor.authorTezel, Ahmet
dc.contributor.authorUnlu, Ercument
dc.date.accessioned2024-06-12T11:12:37Z
dc.date.available2024-06-12T11:12:37Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAtaxia and tremor are rare manifestations of hepatocerebral degeneration due to portovenous shunts. Ammonia is a neurotoxin that plays a significant role in the pathogenesis of hepatic encephalopathy. A 58-year old male patient was assessed with the complaints of gait disturbance, hand tremor, and impairment of speech. His neurological examination revealed dysarthric speech and ataxic gait. Bilateral kinetic tremor was noted, and deep tendon reflexes of the patient were hyperactive. Serum ammonia level was found to be 156.9 mu g/dL. Cranial magnetic resonance (MR) imaging revealed increased signal intensity in bilateral globus pallidus on T1 -weighted axial sections, and bilateral prominent hyperintense lesions in the middle cerebellar peduncles on T2-weighted axial sections. On his abdominal MR portography, multiple portohepatic venous collaterals were noted in the right and left lobes of liver parenchyma in 2D FIESTA axial MR sections. To our knowledge, we reported the first case of acquired hepatocerebral degeneration presenting with cerebral symptoms without any hepatic findings in which clinical improvement was noted, and hyperammonemia disappeared following medical treatment.en_US
dc.identifier.endpage426en_US
dc.identifier.issn0019-1442
dc.identifier.issue11-12en_US
dc.identifier.pmid24555244en_US
dc.identifier.startpage424en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23248
dc.identifier.volume66en_US
dc.identifier.wosWOS:000346684000010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLiteratura Medicaen_US
dc.relation.ispartofIdeggyogyaszati Szemle-Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPortovenous Shunten_US
dc.subjectHepatocerebral Degenerationen_US
dc.subjectTreatmenten_US
dc.subjectPrognosisen_US
dc.subjectVenous Shunten_US
dc.titleREVERSIBLE HEPATOCEREBRAL DEGENERATION-LIKE SYNDROME DUE TO PORTOVENOUS SHUNTSen_US
dc.typeArticleen_US

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