Unknown primary adenocarcinomas: A single-center experience

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dc.authoridHacıbekiroğlu, İlhan/0000-0002-0333-7405
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authoridÖzen, Alaattin/0000-0001-9219-6001;
dc.authorwosidHacıbekiroğlu, İlhan/JCN-7264-2023
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidCicin, Irfan/AAQ-5575-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.contributor.authorUzunoglu, Sernaz
dc.contributor.authorErdogan, Bulent
dc.contributor.authorKodaz, Hilmi
dc.contributor.authorCinkaya, Ahmet
dc.contributor.authorTurkmen, Esma
dc.contributor.authorHacibekiroglu, Ilhan
dc.contributor.authorSari, Ali
dc.date.accessioned2024-06-12T10:50:45Z
dc.date.available2024-06-12T10:50:45Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study aimed to elucidate the clinical and prognostic characteristics of a homogeneous group of patients with cancer of unknown primary (CUP). Between 1999 and 2014, CUP was diagnosed in 159 (1.3%) of 11,742 cancer patients at Trakya University Hospital (Edirne, Turkey). Ninety-seven (61%) of the 159 patients were retrospectively reviewed. Among these, 61 (62.8%) patients with adenocarcinoma were included in this study. The most frequently predicted primary tumor site was the lung (37.7%), and 59% of the patients were smokers. There was a significant relationship between smoking and the lung as a potential primary cancer site (p = 0.042). The most frequent site of metastasis was the liver (60.7%). The median number of metastases per patient was two, but patients with liver metastases had a median of five metastases. The overall median survival time was 7 months. Median survival was significantly longer in patients with a predicted primary site than in patients without the predicted site (7 vs. 6 months, respectively; p = 0.038). When the patients with predicted ovarian and peritoneal tumors were excluded from the comparison, the statistical p value was still close to significant (p = 0.07). Multivariate analysis revealed that smoking, liver metastasis, serum alkaline phosphatase = 92 U/L, and progression in response to chemotherapy were independent predictors of a poor prognosis. The present study identified several independent prognostic factors in patients with unknown primary adenocarcinomas who received chemotherapy. Smoking, the presence of liver metastasis, and response to chemotherapy were independent risk factors for both progression-free and overall survival.en_US
dc.identifier.doi10.17305/bjbms.2016.1495
dc.identifier.endpage297en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue4en_US
dc.identifier.pmid27455119en_US
dc.identifier.scopus2-s2.0-85013072480en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage292en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2016.1495
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18091
dc.identifier.volume16en_US
dc.identifier.wosWOS:000388033500009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenocarcinomaen_US
dc.subjectNeoplasm Metastasisen_US
dc.subjectPrognosisen_US
dc.subjectPrimary Siteen_US
dc.subjectPrognostic-Factorsen_US
dc.subjectPredict Survivalen_US
dc.subjectPrimary Tumoren_US
dc.subjectCarcinomaen_US
dc.subjectCanceren_US
dc.subjectManagementen_US
dc.subjectChemotherapyen_US
dc.subjectCisplatinen_US
dc.subjectModelen_US
dc.titleUnknown primary adenocarcinomas: A single-center experienceen_US
dc.typeArticleen_US

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