ASSOCIATION OF ANGIOTENSINOGEN T174M AND M235T GENE VARIANTS WITH DEVELOPMENT OF HYPERTENSION IN TURKISH SUBJECTS OF TRAKYA REGION

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorBasak, A. Ay
dc.contributor.authorSipahi, T.
dc.contributor.authorUstundag, S.
dc.contributor.authorOzgen, Z.
dc.contributor.authorBudak, M.
dc.contributor.authorSen, S.
dc.contributor.authorSener, S.
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGenetic determinations of human essential (primary) hypertension are discussed reviewing the candidate genes. Angiotensinogen (AGT) gene, coding the precursor of potent vasoactive hormone angiotensin II, in renin- angiotensin-system (RAS) has been reported to be associated with the onset of hypertension. The aim of this study was to investigate the role of variation in the 174 and 235 sites in exon 2 in AGT gene in the developing of primary hypertension in Turkish subjects from Trakya region. Our study involved 136 subjects, 84 hypertensive and 52 gender and age matched controls. T174M and M235T polymorphisms of the AGT gene were investigated using allele specific polymerase chain reaction (PCR) assay and restriction fragment length polymorphism (RFLP). The frequency of genotypes of the variant T174M in the patients with primary hypertension was TT=%73.8, TM=%26.2, and MM=%0.0, that were not different from the controls TT=%73.1, TM=%26.2, and MM=%1.9. And for M235T; the genotype frequencies in patients with primary hypertension were MM=%19.0 MT=%54.8, and TT=%26.2, which were again not significantly different from that of the controls MM=%26.9 MT=%46.2 and TT=%26.9. In conclusion this study, shows that T174M and M235T variants of the AGT gene were not associated with primary hypertension in Turkish subjects from Trakya region.en_US
dc.identifier.doi10.1080/13102818.2008.10817593
dc.identifier.endpage989en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-57749193137en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage984en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2008.10817593
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23596
dc.identifier.volume22en_US
dc.identifier.wosWOS:000261341400020en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenin Angiotensin Systemen_US
dc.subjectAngiotensinogen Geneen_US
dc.subjectT174M Gene Polymorphismen_US
dc.subjectM235T Gene Polymorphismen_US
dc.subjectEssential (Primary) Hypertensionen_US
dc.subjectEssential Arterial-Hypertensionen_US
dc.subjectConverting-Enzyme Geneen_US
dc.subjectMolecular-Basisen_US
dc.subjectPolymorphismen_US
dc.subjectRisken_US
dc.subjectSmokingen_US
dc.subjectObesityen_US
dc.subjectAlleleen_US
dc.titleASSOCIATION OF ANGIOTENSINOGEN T174M AND M235T GENE VARIANTS WITH DEVELOPMENT OF HYPERTENSION IN TURKISH SUBJECTS OF TRAKYA REGIONen_US
dc.typeArticleen_US

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