Increased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in patients with ulcerative colitis

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dc.authoridVural, Özge/0000-0001-7523-7553
dc.authoridUmit, Hasan/0000-0002-3651-4180
dc.authoridTezel, Ahmet/0000-0002-3054-475X
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.authorwosidUmit, Hasan/T-6236-2019
dc.authorwosidVural, Özge/AAJ-6924-2021
dc.contributor.authorPamuk, Gulsum E.
dc.contributor.authorVural, Ozden
dc.contributor.authorTurgut, Burhan
dc.contributor.authorDernir, Muzaffer
dc.contributor.authorUmit, Hasan
dc.contributor.authorTezel, Ahmet
dc.date.accessioned2024-06-12T11:16:52Z
dc.date.available2024-06-12T11:16:52Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt is reported that the incidence of thromboembolism is increased in ulcerative colitis (UC), and hypercoagulability persists even when patients are in remission. We evaluated the association of inflammatory response parameters with UC activity, and activation parameters of the platelets, endothelium, and the coagulation system in UC. Eighteen UC patients and 19 healthy subjects were included in the study. The patients' clinical features were recorded down; whole blood counts and acute phase parameters were evaluated. UC patients were divided into two as active (9 patients) and inactive (9 patients) according to combined clinical activity index (CAI) and endoscopic activity index (EAI) scores. In all subjects, platelet CD62P expression, platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), and platelet microparticles (PMP) were determined by flow cytometry. E-selectin, thrombin-antithrombin complex (TAT) levels in plasma, and sCD40L levels in serum were determined by ELISA. In both active and inactive UC patients, platelet CD62P expression, the percentages of PMC, and PNC were significantly higher than those in the control group (P < 0.01). PMP level was higher in the control group than in inactive UC patients (P = 0.001). sCD40L level was significantly higher in active UC group than in the control group (P < 0.01). EAI score correlated significantly with PMP (r = 0.5, P = 0.04) and sCD40L (r = 0.48, P = 0.044); CAI score had a negative correlation (r = -0.68, P = 0.002) with sE-selectin level. In addition to increased CD62P expression and sCD40L, increased formation of PMC and PNC suggests a role for platelet-leukocyte complex formation together with platelet activation in thromboembolic events observed in UC. (c) 2006 Wiley-Liss, Inc.en_US
dc.identifier.doi10.1002/ajh.20655
dc.identifier.endpage759en_US
dc.identifier.issn0361-8609
dc.identifier.issn1096-8652
dc.identifier.issue10en_US
dc.identifier.pmid16941615en_US
dc.identifier.scopus2-s2.0-33749539332en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://doi.org/10.1002/ajh.20655
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24484
dc.identifier.volume81en_US
dc.identifier.wosWOS:000241140500005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAmerican Journal Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUlcerative Colitisen_US
dc.subjectCD40 Liganden_US
dc.subjectP-Selectinen_US
dc.subjectPlatelet-Monocyte Complexesen_US
dc.subjectPlatelet-Neutrophil Complexesen_US
dc.subjectInflammatory-Bowel-Diseaseen_US
dc.subjectGiant-Cell Arteritisen_US
dc.subject5-Aminosalicylic Aciden_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectElevated Levelsen_US
dc.subjectP-Selectinen_US
dc.subjectMicroparticlesen_US
dc.subjectAtherosclerosisen_US
dc.subjectHemostasisen_US
dc.subjectInhibitionen_US
dc.titleIncreased circulating platelet-neutrophil, platelet-monocyte complexes, and platelet activation in patients with ulcerative colitisen_US
dc.typeArticleen_US

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