Encephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomes

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dc.authoridSimo Canonge, Rafael/0000-0003-0475-3096
dc.authorwosidHommet, Caroline/P-6291-2016
dc.authorwosidDihné, Marcel/G-1995-2010
dc.contributor.authorTamagno, Gianluca
dc.contributor.authorCelik, Yahya
dc.contributor.authorSimo, Rafael
dc.contributor.authorDihne, Marcel
dc.contributor.authorKimura, Kazumi
dc.contributor.authorGelosa, Giorgio
dc.contributor.authorLee, Byung I.
dc.date.accessioned2024-06-12T11:18:59Z
dc.date.available2024-06-12T11:18:59Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The encephalopathy associated with autoimmune thyroid disease (EAATD) is characterized by neurological/psychiatric symptoms, high levels of anti-thyroid antibodies, increased cerebrospinal fluid protein concentration, non-specific electroencephalogram abnormalities, and responsiveness to the corticosteroid treatment in patients with an autoimmune thyroid disease. Almost all EAATD patients are affected by Hashimoto's thyroiditis (HT), although fourteen EAATD patients with Graves' disease (GD) have been also reported. Methods: We have recorded and analyzed the clinical, biological, radiological, and electrophysiological findings and the data on the therapeutic management of all GD patients with EAATD reported so far as well as the clinical outcomes in those followed-up in the long term. Results: Twelve of the fourteen patients with EAATD and GD were women. The majority of GD patients with EAATD presented with mild hyperthyroidism at EAATD onset or shortly before it. Active anti-thyroid autoimmunity was detected in all cases. Most of the patients dramatically responded to corticosteroids. The long term clinical outcome was benign but EAATD can relapse, especially at the time of corticosteroid dose tapering or withdrawal. GD and HT patients with EAATD present with a similar clinical, biological, radiological, and electrophysiological picture and require an unaffected EAATD management. Conclusions: GD and HT equally represent the possible background condition for the development of EAATD, which should be considered in the differential diagnosis of all patients with encephalopathy of unknown origin and an autoimmune thyroid disease, regardless of the nature of the underlying autoimmune thyroid disease.en_US
dc.identifier.doi10.1186/1471-2377-10-27
dc.identifier.issn1471-2377
dc.identifier.pmid20426819en_US
dc.identifier.scopus2-s2.0-77951603993en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/1471-2377-10-27
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25039
dc.identifier.volume10en_US
dc.identifier.wosWOS:000278227300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHashimotos Encephalopathyen_US
dc.subjectAlpha-Enolaseen_US
dc.subjectPrevalenceen_US
dc.subjectRemissionen_US
dc.titleEncephalopathy associated with autoimmune thyroid disease in patients with Graves' disease: clinical manifestations, follow-up, and outcomesen_US
dc.typeArticleen_US

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