Effect of Verapamil on Reduction of Peri-implant Capsular Thickness

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dc.contributor.authorBenlier, Erol
dc.contributor.authorUnal, Yasin
dc.contributor.authorUsta, Ufuk
dc.contributor.authorTop, Husamettin
dc.contributor.authorAygit, Ahmet C.
dc.date.accessioned2024-06-12T11:12:17Z
dc.date.available2024-06-12T11:12:17Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSilicone is a material commonly used in reconstructive and aesthetic surgery, but capsular formation is a very frequent complication of silicone implants. This study aimed to investigate whether verapamil, a calcium-channel blocker, can reduce the thickness of the peri-implant capsule in rats when it is instilled into the subcutaneous pockets. For this study, 60 female Wistar albino rats were used, and cubes of silicone blocks (10 x 10 x 5 mm) were crafted. The rats were divided into five groups of 12 each, and the groups were distinguished according to the use of silicone and artificially created hematoma relevant to administration of a single dose of 5 mg verapamil (Isoptin). The control group was left without silicone. In two of the four silicone groups, hematoma was artificially created around the silicone by a 1-ml injection of blood. The implants were removed 6 months later, and capsulectomy was performed. Under light microscopic examination, no severe inflammation was observed in any of the capsule tissues. Additionally, the thickness of the capsule was measured and found to be significantly reduced statistically in all the verapamil-treated groups, including the groups with the artificially created hematoma. In conclusion, based on the statistically significant data obtained in this study, subcutaneous verapamil administration may be a useful adjunct for preventing formation of capsular contracture after silicone implantations. This preliminary work in rats should be confirmed with larger mammals before carefully controlled clinical trials are considered.en_US
dc.identifier.doi10.1007/s00266-008-9288-6
dc.identifier.endpage575en_US
dc.identifier.issn0364-216X
dc.identifier.issue4en_US
dc.identifier.pmid19101759en_US
dc.identifier.scopus2-s2.0-70349602286en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage570en_US
dc.identifier.urihttps://doi.org/10.1007/s00266-008-9288-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23101
dc.identifier.volume33en_US
dc.identifier.wosWOS:000268292700015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeri-Implant Capsular Formationen_US
dc.subjectSiliconeen_US
dc.subjectVerapamilen_US
dc.subjectSilicone Breast Implantsen_US
dc.subjectIntralesional Verapamilen_US
dc.subjectChannel Blockersen_US
dc.subjectContractureen_US
dc.subjectComplicationsen_US
dc.subjectInjectionen_US
dc.subjectOutcomesen_US
dc.subjectSurgeryen_US
dc.titleEffect of Verapamil on Reduction of Peri-implant Capsular Thicknessen_US
dc.typeArticleen_US

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