Roles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase

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dc.authoridBAHTİYAR, NURTEN/0000-0003-2420-8415
dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridCinemre, Fatma Behice/0000-0002-1972-1575;
dc.authorwosidBAHTİYAR, NURTEN/D-6468-2019
dc.authorwosidBAHTİYAR, NURTEN/IZP-9481-2023
dc.authorwosidYILDIZ, Mustafa/B-7520-2016
dc.authorwosidAydemir, Birsen/HKO-5522-2023
dc.authorwosidCinemre, Hakan/AAD-7506-2021
dc.authorwosidCinemre, Fatma Behice/JHS-8430-2023
dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.contributor.authorCinemre, Fatma Behice Serinkan
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGulyasar, Tevfik
dc.contributor.authorCinemre, Hakan
dc.contributor.authorTuten, Abdullah
dc.contributor.authorYolmaz, Nevin
dc.contributor.authorYoldoz, Mustafa
dc.date.accessioned2024-06-12T11:12:48Z
dc.date.available2024-06-12T11:12:48Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Preeclampsia (PE) is a complex disease and the underlying mechanisms are not known yet. It is well known that selenium and oxidative stress play a role in the pathogenesis of various diseases as well as PE. The aim of the study was to investigate the changes in selenium status, as an essential trace element, and selenoprotein K (SelK), a newly described selenoprotein which has been suggested to have an antioxidant function in some tissues in patients with preeclampsia. We also aimed at investigating their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidase (GPx) activities. Materials and methods: 38 healthy pregnant and 48 pregnant women with PE were included in the study. Serum selenium levels were measured by graphite-furnace atomic absorption spectrophotometry. Plasma TBARS levels were analyzed by spectrophotometric method; GPx activities, 8OHdG, and SelK levels were determined by ELISA. Results: Plasma TBARS and 8OHdG levels were found to be increased in the PE group compared to the healthy pregnant group. Plasma SelK levels and GPx activities were found to be lower in the PE group than in the healthy control group. However, there was no significant difference in serum selenium levels between two groups. Furthermore, a significant correlation was determined between plasma SelK levels and GPx activities in PE patients group (r = 0.743; p < 0.01). Likewise, a significant positive correlation was found between plasma 8OHdG and TBARS levels (r = 0.457; p < 0.01), serum selenium levels and plasma GPx activities (r = 0.663; p < 0.01), serum selenium and plasma SelK levels (r = 0.851; p < 0.01) in PE. Conclusion: Our findings indicated that a selenoprotein SelK and a selenoenzyme GPx play a role in the etiopathogenesis of PE. Decreases in these antioxidant systems were associated with increase in lipid and DNA oxidation in PE patients. Underlying mechanisms of SelK and its interactions with selenium status and GPx in PE should be clarified in details with further studies.en_US
dc.identifier.doi10.5414/TEX01512
dc.identifier.endpage130en_US
dc.identifier.issn0946-2104
dc.identifier.issue3en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.5414/TEX01512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23292
dc.identifier.volume35en_US
dc.identifier.wosWOS:000435533800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofTrace Elements And Electrolytesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectSeleniumen_US
dc.subjectTBARSen_US
dc.subject8ohdgen_US
dc.subjectGpxen_US
dc.subjectSelken_US
dc.subjectSuperoxide-Dismutase Activitiesen_US
dc.subjectTrace-Elementsen_US
dc.subjectHypertensive Disordersen_US
dc.subjectMalondialdehyde Levelsen_US
dc.subjectStressen_US
dc.subjectAntioxidanten_US
dc.subjectPregnancyen_US
dc.subjectMetalsen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.titleRoles of selenoprotein K and selenium status in the etiopathogenesis of preeclampsia: Their relationships with maternal lipid peroxidation, oxidative DNA damage, and glutathione peroxidaseen_US
dc.typeArticleen_US

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