Assessment of tissue viability after frostbite injury by technetium-99m-sestamibi scintigraphy in an experimental rabbit model

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X;
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.authorwosidTurkyilmaz, Murat/AAK-7876-2020
dc.contributor.authorSarikaya, I
dc.contributor.authorAygit, AC
dc.contributor.authorCandan, L
dc.contributor.authorSarikaya, A
dc.contributor.authorTürkyilmaz, M
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:02:18Z
dc.date.available2024-06-12T11:02:18Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFrostbite causes injury to the tissue by direct ice-crystal formation at the cellular level with cellular dehydration and microvascular occlusion. Muscle that initially appears viable on reperfusion may subsequently become necrotic because of microcirculatory collapse. Since muscle is a sensitive tissue in frostbite injury, we used technetium-99m-sestamibi limb scintigraphy to assess tissue viability in an experimental rabbit model. Twelve rabbits were used for this investigation. The right hind limb of the rabbits was immersed to the ankle joint in a container filled with 90% ethanol at -25 degrees C for 10 min. Frostbitten limbs were allowed to thaw in air at room temperature. Imaging and pathological examination of the affected limbs were performed 2 h, 24 h, 48 h and 72 h after freezing. In 2-h images, initial hypoperfusion was seen that corresponded to circulatory collapse. In 24-h images, there was hyperperfusion (so-called period of temporary reperfusion), corresponding to circulatory restoration. In 48-h images, a second hypoperfusion corresponded to viable but ischaemic tissue. In 72-h images, there was non-perfusion of the limb that correlated with the pathologically determined diagnosis of necrosis. All scintigraphic patterns correlated with pathological findings. We suggest that these scintigraphic patterns in soft tissue may be helpful in distinguishing between frank infarction and reversible ischemia and therefore may be useful in selecting early therapeutic or surgical interventions to salvage bone and soft tissue. Further studies ape needed to show the usefulness of Tc-99m sestamibi scintigraphy in clinical frostbite cases.en_US
dc.identifier.doi10.1007/PL00006660
dc.identifier.endpage45en_US
dc.identifier.issn0340-6997
dc.identifier.issue1en_US
dc.identifier.pmid10654145en_US
dc.identifier.scopus2-s2.0-0033954532en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1007/PL00006660
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21230
dc.identifier.volume27en_US
dc.identifier.wosWOS:000084632000006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofEuropean Journal Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFrostbiteen_US
dc.subjectScintigraphyen_US
dc.subjectTechnetium-99m-Sestamibien_US
dc.subjectCoronary-Artery Diseaseen_US
dc.subjectMyocardial Viabilityen_US
dc.subjectTc-99men_US
dc.subjectPyrophosphateen_US
dc.subjectIsonitrileen_US
dc.subjectPerfusionen_US
dc.titleAssessment of tissue viability after frostbite injury by technetium-99m-sestamibi scintigraphy in an experimental rabbit modelen_US
dc.typeArticleen_US

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