Combination therapy using sertraline with sleep deprivation and light therapy compared to sertraline monotherapy for major depressive disorder

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dc.authoridvardar, mehmet erdal/0000-0002-5836-6174;
dc.authorwosidCaliyurt, Okan/ABE-7339-2020
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.authorwosidvardar, mehmet erdal/AAB-7287-2021
dc.contributor.authorGüdücü, F
dc.contributor.authorÇaliyurt, O
dc.contributor.authorVardar, E
dc.contributor.authorTuglu, C
dc.contributor.authorAbay, E
dc.date.accessioned2024-06-12T11:14:13Z
dc.date.available2024-06-12T11:14:13Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Bright light therapy is effective and well tolerated in seasonal affective disorder and some studies reported an antidepressant effect of bright light also in non-seasonal depression. On the other hand, total sleep deprivation leads to a rapid and marked improvement of mood in 60% of depressed patients. Combinations of antidepressant medication with those somatic therapies are generally indicated. The aim of this study was to compare the efficacy of the combination of sertraline and partial sleep deprivation or light therapy with sertraline monotherapy in the treatment of major depression. Method: Thirty-seven patients with major depressive disorder were randomly allocated into 3 treatment groups. Thirteen were treated with sertraline and late partial sleep deprivation, 13 with sertraline and bright light therapy and 11 sertaline monotherapy as a control group. Outcome measures included daily (first 15 days) and weekly Hamilton Rating Scale for Depression and biweekly Hamilton Anxiety Rating Scale. Results: Partial sleep deprivation group improved significantly and more rapidly. Accelerated treatment response was shown in sleep deprivation group that improvement was observed after the third day. Bright light and sleep deprivation combinations with sertraline were more effective than sertraline monotherapy for accompanied anxiety in depression. Conclusion: Late partial sleep deprivation in combination with sertraline can accelerate and increase the treatment response in non-seasonal major depressive disorder.en_US
dc.identifier.endpage251en_US
dc.identifier.issn1300-2163
dc.identifier.issue4en_US
dc.identifier.pmid16362843en_US
dc.identifier.startpage245en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23852
dc.identifier.volume16en_US
dc.identifier.wosWOS:000234155700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep Deprivationen_US
dc.subjectPhototherapyen_US
dc.subjectSertralineen_US
dc.subjectMajor Depressionen_US
dc.subjectSeasonal Affective-Disorderen_US
dc.subjectObsessive-Compulsive Disorderen_US
dc.subjectPlacebo-Controlled Trialen_US
dc.subjectNonseasonal Depressionen_US
dc.subjectBright Lighten_US
dc.subjectEndogenous-Depressionen_US
dc.subjectBipolar Depressionen_US
dc.subjectPhototherapyen_US
dc.subjectEfficacyen_US
dc.subjectPhaseen_US
dc.titleCombination therapy using sertraline with sleep deprivation and light therapy compared to sertraline monotherapy for major depressive disorderen_US
dc.typeArticleen_US

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