Synthesis, structural aspects, antimicrobial activity and ion transport investigation of five new [1+1] condensed cycloheterophane peptides

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridZaim, Omer/0000-0002-3472-5611
dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridGurbuz, Mustafa Ulvi/0000-0002-8684-5746
dc.authorwosidDulger, Basaran/AAF-7965-2019
dc.authorwosidZaim, Omer/Q-7770-2019
dc.authorwosidDulger, Basaran/J-3194-2016
dc.authorwosidZaim, Ömer/AAI-1470-2021
dc.contributor.authorZaim, Omer
dc.contributor.authorAghatabay, Naz Mohammed
dc.contributor.authorGurbuz, Mustafa Ulvi
dc.contributor.authorBaydar, Caglar
dc.contributor.authorDulger, Basaran
dc.date.accessioned2024-06-12T10:52:01Z
dc.date.available2024-06-12T10:52:01Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFive novel [1+1] condensed cycloheterophane peptides were synthesized via reaction of pyridine-2,6-bis(2-aminothiophenoxymethyl) with several diacid chlorides: glutaryl dichloride, adipoyl dichloride, 2,2'-thiodiacetyl chloride, dithiodiglycoloyl chloride and 3,3'-thiodipropionoyl chloride combinations (L-1-L-5). The compounds were characterized by elemental analyses, mass, FT-IR, H-1, and C-13 NMR spectral data. The antimicrobial activities of the compounds were evaluated using the disk diffusion method in dimethyl sulfoxide as well as the minimal inhibitory concentration dilution method, against several bacteria and yeast cultures. The results were compared with those of commercial antibiotic and antifungal agents. Structure activity relationships were also discussed. Permeability of compound L-5 against Na+ and K+ were also investigated.en_US
dc.description.sponsorshipFatih University Scientific Research Centre [P50021004_G1452]; Trakya University [TUBAP-2010/174]en_US
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre ( Project-P50021004_G1452) and the Trakya University (Grant # TUBAP-2010/174) for their financial support. Dr. Ahmet Ceyhan Goren and Gokhan Bilsel (TUBITAK-UME), is acknowledged for the Mass analysis.en_US
dc.identifier.doi10.1007/s10847-012-0282-x
dc.identifier.endpage159en_US
dc.identifier.issn1388-3127
dc.identifier.issn1573-1111
dc.identifier.issue1-4en_US
dc.identifier.scopus2-s2.0-84893814896en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1007/s10847-012-0282-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18572
dc.identifier.volume78en_US
dc.identifier.wosWOS:000334496700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Inclusion Phenomena And Macrocyclic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobialen_US
dc.subjectCycloheterophaneen_US
dc.subjectDiffusionen_US
dc.subjectIon Transporten_US
dc.subjectPermeabilityen_US
dc.subjectThia Macrocyclic-Compoundsen_US
dc.subjectPhane Nomenclatureen_US
dc.subjectFt-Iren_US
dc.subjectComplexationen_US
dc.subjectDerivativesen_US
dc.subjectCytotoxicityen_US
dc.subjectBindingen_US
dc.subjectRamanen_US
dc.titleSynthesis, structural aspects, antimicrobial activity and ion transport investigation of five new [1+1] condensed cycloheterophane peptidesen_US
dc.typeArticleen_US

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