Pulmonary alveolar proteinosis in a patient with acute lymphoid leukemia regression after G-CSF therapy
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Pulmonary alveolar proteinosis (PAP) is the intra-alveolar accumulation of periodic-acid schiff (PAS) positive material. PAP is one of the underrecognized causes of pulmonary infiltrates in patients with hematologic malignancies. Here, we present a patient with acute lymphoid leukemia (ALL) in first remission that developed fever and diffuse pulmonary infiltrates during the neutropenic stage of consolidation chemotherapy. The histopathologic examination of bronchoalveolar lavage (BAL) fluid and transbronchial biopsy specimen demonstrated the presence of PAS-positive eosinophilic material. Empirical antibiotherapy and granulocyte-colony stimulating factor (G-CSF) were given. After the correction of neutropenia with G-CSF, the patient's fever disappeared, acute phase reactants decreased, pulmonary infiltrates resolved. We present this case because it was the first patient in whom the correction of neutropenia with G-CSF was followed by resolution of PAP.
Açıklama
Anahtar Kelimeler
Pulmonary Alveolar Proteinosis, Acute Lymphoid Leukemia, Granulocyte-Colony Stimulating Factor (G-CSF), Neutropenia, Chronic Myelogenous Leukemia, Colony-Stimulating Factor, Acute Myeloid-Leukemia, Respiratory-Failure, Deficient Mice, Transplantation
Kaynak
Leukemia & Lymphoma
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
44
Sayı
5
