The results of purified protein derivative test in ankylosing spondylitis patients: clinical features, HRCT results and relationship with TNF-blocker usage

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dc.authorwosidKöker, Ibrahim Hakkı/AAO-8538-2021
dc.authorwosidCakir, Necati/AAG-7283-2019
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorYesil, Yusuf
dc.contributor.authorDonmez, Salim
dc.contributor.authorUnlu, Ercument
dc.contributor.authorKoker, Ibrahim Hakki
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T10:51:52Z
dc.date.available2024-06-12T10:51:52Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, we evaluated the clinical features, treatment modalities, including TNF-blockers, purified protein derivative (PPD) test, chest X-ray and HRCT results in our AS patients. We evaluated the clinical features, disease activity and PPD results in 88 AS patients (72 males, 16 females, mean age: 38.3 +/- 10) diagnosed at our center. 119 RA, 28 SLE and 27 gouty arthritis patients followed up at the same time period were taken as the control group. The mean disease duration in AS patients was 12.6 +/- 8.3 years. The frequency of PPD positivity in AS patients (77.3%) was similar to that in gouty arthritis (70.4%) patients; and significantly higher than the frequency in SLE (21.4%) and RA (35.3%) patients (P values < 0.001). There was a chest X-ray abnormality in 20 AS patients (22.7%). When subjects (11 patients, 12.5%) with apical fibrosis, aspergillosis, previous or active TB on chest X-ray and/or HRCT were compared to others; it was observed that they were older (P < 0.001), had longer disease duration (P = 0.006); and less chest expansion (P = 0.01). Fifty patients were administered TNF-blockers. The PPD test was positive in 38 of patients (76%) using TNF-blockers. All of these patients were given isoniazid prophylaxis. After a median follow up of 18 months, TB did not develop. In Turkey which is a country with a relatively high incidence of TB, in spite of a higher frequency of PPD positivity in AS patients compared to RA and SLE patients, TNF-blockers did not result in any TB with suitable prophylaxis.en_US
dc.identifier.doi10.1007/s00296-008-0665-x
dc.identifier.endpage183en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue2en_US
dc.identifier.pmid18682953en_US
dc.identifier.scopus2-s2.0-55949124424en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage179en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-008-0665-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18490
dc.identifier.volume29en_US
dc.identifier.wosWOS:000260542800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectPurified Protein Derivative (PPD) Testen_US
dc.subjectTuberculosis (TB)en_US
dc.subjectTNF Blockersen_US
dc.subjectResolution Computed-Tomographyen_US
dc.subjectPulmonary Involvementen_US
dc.subjectLung Findingsen_US
dc.subjectAspergillosisen_US
dc.subjectCten_US
dc.titleThe results of purified protein derivative test in ankylosing spondylitis patients: clinical features, HRCT results and relationship with TNF-blocker usageen_US
dc.typeArticleen_US

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