Loratidine improves ischemic parameters of exercise stress test in patients with acute myocardial infarction

Basit Öğe Kaydı
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorErdogan, O
dc.contributor.authorAltun, A
dc.contributor.authorGazi, S
dc.contributor.authorOzbay, G
dc.date.accessioned2024-06-12T11:19:06Z
dc.date.available2024-06-12T11:19:06Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study sought to determine whether adding an anti-histaminic medication, loratidine, to anti-ischemic treatment would ameliorate or improve ischemic parameters induced by exercise stress test in patients who suffered an acute myocardial infarction. Methods: Twenty stable patients with acute inferior myocardial infarction who had a positive EST were randomly allocated into 2 groups, A and B. Patients in group A and B received a 10 mg loratidine tablet added daily to their anti-ischemic regimen for 7 days during the second and third week post-event, respectively. As the end of each period they underwent an exercise stress test (EST). Exercise parameters in each group were then compared before and after loratidine therapy. Results: Both groups showed improvements in exercise parameters after loratidine therapy compared to a basal EST results. STmax (group A: 1.9+/-0.74 vs 0.9+/-1.29 mm, P=.046, group B: 2.5+/-0,7 1 vs 1.4+/-1.17 mm, P=.041), STlead (group A: 3.4+/-1.08 vs 1.5+/- 2.12, P=.027;group B: 4.6+/-1.71 vs 2.22+/- 2.25, P=.011, STlead group A: 4.7 +/-2.18 vs 2.1+/-3.11 mm, P=.024; group B: 7.9+/-2.92 vs 3.33+/-3.81 mm, P =.005). Conclusion: Our study revealed that loratidine, a histamine-1 receptor blocker, improves ischemic parameters of EST when given as additive therapy to a routine anti-ischemic regimen during the sub-acute phase of myocardial infarction.en_US
dc.identifier.doi10.1016/j.ahj.2004.04.048
dc.identifier.issn0002-8703
dc.identifier.issue6en_US
dc.identifier.pmid15632861en_US
dc.identifier.scopus2-s2.0-10644277010en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ahj.2004.04.048
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25080
dc.identifier.volume148en_US
dc.identifier.wosWOS:000225970400040en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby, Incen_US
dc.relation.ispartofAmerican Heart Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectImmunoglobulin-E Responseen_US
dc.subjectCoronary-Arteriesen_US
dc.subjectMast-Cellsen_US
dc.subjectMechanismen_US
dc.subjectRuptureen_US
dc.subjectErosionen_US
dc.subjectAnginaen_US
dc.subjectSpasmen_US
dc.subjectSiteen_US
dc.titleLoratidine improves ischemic parameters of exercise stress test in patients with acute myocardial infarctionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu