Association Between Plasma Asprosin Levels and Gestational Diabetes Mellitus

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dc.authoridAytürk Salt, Semra/0000-0002-1560-3459
dc.authoridSALT, OMER/0000-0002-5557-6627
dc.authorwosidAytürk Salt, Semra/U-4265-2017
dc.contributor.authorBoz, Ibrahim Bekir
dc.contributor.authorSalt, Semra Ayturk
dc.contributor.authorSalt, Omer
dc.contributor.authorSayin, Niyazi Cenk
dc.contributor.authorDibirdik, Ilker
dc.date.accessioned2024-06-12T10:52:38Z
dc.date.available2024-06-12T10:52:38Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: This study sought to investigate whether asprosin can be used in the diagnosis of GDM or for diagnostic purposes in high-risk pregnancies, along with a review of other parameters that may be associated with serum asprosin levels. Patients and Methods: The study investigated the association between gestational diabetes mellitus (GDM) and asprosin levels. A total of 93 participants; 30 patients with GDM, 33 healthy pregnant women with normal glucose tolerance (NGT), and 30 healthy non-diabetic women (control group) at the Endocrinology and Metabolic Diseases outpatient clinic of a tertiary care university hospital were enrolled in the study. Patients with GDM and NGT were examined in terms of GDM between the 24th and 28th week of pregnancy (2nd trimester). Patient data were collected during routine examinations, and asprosin levels were measured using the ELISA method. All participants underwent testing for measurements of serum hemoglobin, insulin, C-peptide, fasting plasma glucose, and glycated hemoglobin (HbA1c) levels following a fasting period of at least eight hours. Results: Asprosin levels were higher in pregnant women with NGT and with GDM versus controls (Control-NGT asprosin, p = 0.001; Control-GDM asprosin, p = 0.001). Pregnant women with GDM had higher asprosin levels than those with NGT (p = 0.001). In detecting GDM in pregnant women, an asprosin cutoff value of >31.709 ng/mL yielded a sensitivity of 93.3%, specificity of 90.9%, positive predictive value of 90.3%, and negative predictive value of 93.75% (p < 0.001). Conclusion: Serum asprosin levels can potentially be used as a marker in the diagnosis of GDM.en_US
dc.identifier.doi10.2147/DMSO.S424651
dc.identifier.endpage2521en_US
dc.identifier.issn1178-7007
dc.identifier.pmid37641645en_US
dc.identifier.scopus2-s2.0-85169087358en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2515en_US
dc.identifier.urihttps://doi.org/10.2147/DMSO.S424651
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18780
dc.identifier.volume16en_US
dc.identifier.wosWOS:001108555100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDiabetes Metabolic Syndrome And Obesityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsprosinen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectInsulin Resistanceen_US
dc.subjectPregnancyen_US
dc.subjectPregnant-Womenen_US
dc.titleAssociation Between Plasma Asprosin Levels and Gestational Diabetes Mellitusen_US
dc.typeArticleen_US

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