Short-Term Diet Restriction but Not Alternate Day Fasting Prevents Cisplatin-Induced Nephrotoxicity in Mice

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dc.authoridŞAHİN, KAZIM/0000-0002-6459-1853
dc.authoridSahin, Kazim/0000-0001-9542-5244
dc.authoridKorkaya, Hasan/0000-0002-0719-5862
dc.authoridKilic, Ertugrul/0000-0001-6494-8923
dc.authoridYalcin, Esra/0000-0002-1064-7989
dc.authoridBeker, Mustafa/0000-0002-9476-8488
dc.authorwosidŞAHİN, KAZIM/AAG-2742-2019
dc.authorwosidSahin, Kazim/D-5625-2009
dc.authorwosidCaglayan, Aysun/HII-9128-2022
dc.authorwosidBeker, Mustafa Caglar/ABH-2222-2020
dc.authorwosidKorkaya, Hasan/ABD-6282-2020
dc.authorwosidKorkaya, Hasan/GRY-1016-2022
dc.authorwosidKilic, Ertugrul/W-4563-2018
dc.contributor.authorGunebakan, Evrin
dc.contributor.authorYalcin, Esra
dc.contributor.authorCikler Dulger, Esra
dc.contributor.authorYigitbasi, Ahmet
dc.contributor.authorAtes, Nilay
dc.contributor.authorCaglayan, Aysun
dc.contributor.authorBeker, Mustafa C.
dc.date.accessioned2024-06-12T10:56:34Z
dc.date.available2024-06-12T10:56:34Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCisplatin (CP) is one of the most preferred platinum-containing antineoplastic drugs. However, even in nontoxic plasma concentrations, it may cause kidney injury. To be able to increase its effective pharmacological dose, its side effects need to be regarded. Diet restriction (DR) has been demonstrated to improve cellular survival in a number of disorders. In this context, we investigated the role of DR in CP-induced nephrotoxicity (CPN). Besides alternate DR, animals were exposed to DR for 3 days prior or after CP treatment. Here, we observed that both 3 days of DR reverses the nephrotoxic effect of CP, which was associated with improved physiological outcomes, such as serum creatine, blood-urea nitrogen and urea. These treatments significantly increased phosphorylation of survival kinases PI3K/Akt and ERK-1/2 and decreased the level of stress kinase JNK were noted. In addition, the activation level of signal transduction mediator p38 MAPK phosphorylation was higher particularly in both three-day DR groups. Next, animals were fed with carbohydrate-, protein- or fat-enriched diets in the presence of CP. Results indicated that not only fasting but also dietary content itself may play a determinant role in the severity of CPN. Our data suggest that DR is a promising approach to reduce CPN by regulating metabolism and cell signaling pathways.en_US
dc.description.sponsorshipTurkish Academy of Science (TUBA)en_US
dc.description.sponsorshipThis research was funded by the Turkish Academy of Science (TUBA).en_US
dc.identifier.doi10.3390/biomedicines8020023
dc.identifier.issn2227-9059
dc.identifier.issue2en_US
dc.identifier.pmid32028692en_US
dc.identifier.scopus2-s2.0-85080914050en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/biomedicines8020023
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19842
dc.identifier.volume8en_US
dc.identifier.wosWOS:000519109200016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofBiomedicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCisplatinen_US
dc.subjectFastingen_US
dc.subjectRenal Protectionen_US
dc.subjectAcute Kidney Injuryen_US
dc.subjectNephrotoxicityen_US
dc.subjectMAPK Pathwayen_US
dc.subjectMolecular-Mechanismsen_US
dc.subjectRenal Injuryen_US
dc.subjectSurvivalen_US
dc.subjectInflammationen_US
dc.subjectProgressionen_US
dc.subjectProtectsen_US
dc.titleShort-Term Diet Restriction but Not Alternate Day Fasting Prevents Cisplatin-Induced Nephrotoxicity in Miceen_US
dc.typeArticleen_US

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