CD11c expression in chronic lymphocytic leukemia revisited, related with complications and survival

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dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridUmit, Elif/0000-0001-5589-3000
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.contributor.authorUmit, E. G.
dc.contributor.authorBaysal, M.
dc.contributor.authorDurmus, Y.
dc.contributor.authorDemir, A. M.
dc.date.accessioned2024-06-12T10:56:30Z
dc.date.available2024-06-12T10:56:30Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Chronic lymphocytic leukemia (CLL) is a disorder of mature but dysfunctional monoclonal B cells. Microenvironment, antigenic stimulation and genetical mutations are demonstrated in etiopathogenesis. We aimed to evaluate the expression of CD11c in patients with CLL and its possible clinical significance. Methods: Data of 259 patients with CLL between 2010 and 2016 in Trakya University Faculty of Medicine, including age at diagnosis, sex, whole blood count, stage, percentage of CLL cells in bone marrow, line of treatments, development of Richter's transformation and secondary tumors, autoimmune complications, IgG level, prognostic cytogenetic analysis, and length of survival were recorded from files. Results: 151 patients were male (58.3%) and 108 were male (41.7%). Mean age was 70 (21-92)years. CD11c was observed to be positive (>%20) in 103 patients (39.8%). Development of Richter's transformation, secondary tumors and ITP was significantly frequent in patients with CD11c positivity (P values .000, .003, .000 respectively). Also, IgG levels were significantly lower in this group (P=.000). Hemoglobin level, RAI stage and bone marrow CLL infiltration percentage were statistically related with CD11c (P values .036, .037, .000 respectively). Finally, CD11c was statistically related (in positive group 70 months, negative group 79 months, P=.001). Conclusion: CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality.en_US
dc.identifier.doi10.1111/ijlh.12695
dc.identifier.endpage556en_US
dc.identifier.issn1751-5521
dc.identifier.issn1751-553X
dc.identifier.issue5en_US
dc.identifier.pmid28603911en_US
dc.identifier.scopus2-s2.0-85020440274en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage552en_US
dc.identifier.urihttps://doi.org/10.1111/ijlh.12695
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19800
dc.identifier.volume39en_US
dc.identifier.wosWOS:000410782200024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal Of Laboratory Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Lymphocytic Leukemiaen_US
dc.subjectImmunophenotypic Analysisen_US
dc.subjectCells Expressen_US
dc.subjectAntigenen_US
dc.titleCD11c expression in chronic lymphocytic leukemia revisited, related with complications and survivalen_US
dc.typeArticleen_US

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