Antioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats

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dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorToydemir, Toygar
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorOguz, Serhat
dc.contributor.authorErenoglu, Cengiz
dc.date.accessioned2024-06-12T10:58:59Z
dc.date.available2024-06-12T10:58:59Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH+curcumin; each group contains eight animals. The rats in curcumin-treated groups were given curcumin (in a dose of 100mg/kg body weight) once a day orally for 7days, starting 3days prior to hepatectomy operation. At 7days after resection, liver samples were collected. The malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated 2-deoxyuridine, 5-triphosphate nick end-labeling assay, and apoptotic index (AI) were evaluated at 7days after hepatectomy. As a result, curcumin significantly increased MI and PI and significantly decreased AI in PH rats. Additionally, curcumin remarkably inhibited MDA elevation, restored impaired antioxidant SOD activity and GSH level and also attenuated hepatic vacuolar degeneration and sinusoidal congestion. These results suggested that curcumin treatment had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative, antiapoptotic, and proliferative properties.en_US
dc.identifier.doi10.1177/0748233712469658
dc.identifier.endpage172en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid23299190en_US
dc.identifier.scopus2-s2.0-84921779221en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage162en_US
dc.identifier.urihttps://doi.org/10.1177/0748233712469658
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20272
dc.identifier.volume31en_US
dc.identifier.wosWOS:000348905300006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectPartial Hepatectomyen_US
dc.subjectOxidative Stressen_US
dc.subjectImmunohistochemistryen_US
dc.subjectTUNELen_US
dc.subjectRaten_US
dc.subjectCell Nuclear Antigenen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectHepatocellular-Carcinomaen_US
dc.subjectOxidative Stressen_US
dc.subjectMitochondrialen_US
dc.subjectHepatocytesen_US
dc.subjectInhibitionen_US
dc.subjectExpressionen_US
dc.subjectApoptosisen_US
dc.subjectNecrosisen_US
dc.titleAntioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in ratsen_US
dc.typeArticleen_US

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