The association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish men

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dc.authoridArda, Ersan/0000-0002-5430-6561
dc.authoridAkdeniz, Esra/0000-0002-3549-5416
dc.authorwosidArda, Ersan/L-7357-2016
dc.authorwosidAkdeniz, Esra/AAC-6112-2020
dc.contributor.authorArda, Ersan
dc.contributor.authorAy, Arzu
dc.contributor.authorAkdere, Hakan
dc.contributor.authorAkdeniz, Esra
dc.date.accessioned2024-06-12T11:00:33Z
dc.date.available2024-06-12T11:00:33Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSeveral studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED). However, currently controversial results have been reported due to their significant heterogeneity. The present study aimed to assess the genotypic distribution and the allelic frequency of Intron 4 VNTR and Glu298Asp gene polymorphisms in vasculogenic ED patients compared to healthy controls of a specific region of Turkey. A total of 75 patients with ED (median age: 56, IQR:10.5) and 75 healthy controls (median age: 56, IQR:10.5) were prospectively analyzed. All subjects were equally evaluated by the same physician with detailed history-taking, physical examination, International Index of Erectile Function (IIEF) questionnaire, and blood tests (incl. glucose, testosterone, triglyceride and total cholesterol level). Those with an IIEF score under 26 were considered to have ED, by classifying them according to their scores as mild (22-25), moderate (11-21) and severe (1-10) ED. Color doppler ultrasonography was carried out in patients with an IIEF score <22. Hypertension, diabetes mellitus, coronary artery disease, and smoking status were significantly associated with the ED group compared to control subjects with p values of <0.001, <0.001, 0.002 and <0.001, respectively. Overall genotype frequencies was 47 (31%) a/a, 22 (15%) a/b, 82 (55%) b/b for Intron 4 VNTR and 56 (37%) GG, 78 (52%) GT, 16 (11%) TT for the Glu298Asp polymorphism. The frequencies of Intron 4 VNTR a/a allele and Glu298Asp GT allele were associated with severe ED, while a/b and TT were associated with moderate or mild, and b/b and GG were associated with no ED. In contrast to Glu298Asp, statistically significant differences in genotypic frequencies of Intron 4 VNTR gene polymorphism between ED and control subjects was established.en_US
dc.identifier.doi10.1080/19396368.2019.1601792
dc.identifier.endpage389en_US
dc.identifier.issn1939-6368
dc.identifier.issn1939-6376
dc.identifier.issue5en_US
dc.identifier.pmid30977424en_US
dc.identifier.scopus2-s2.0-85064489607en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1080/19396368.2019.1601792
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20880
dc.identifier.volume65en_US
dc.identifier.wosWOS:000466651200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofSystems Biology In Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectEnosen_US
dc.subjectGene Polymorphismen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectEnos Geneen_US
dc.subjectG894t Polymorphismsen_US
dc.subjectSynthase Geneen_US
dc.subjectRisk-Factoren_US
dc.subjectSildenafilen_US
dc.subjectT-786cen_US
dc.subjectI/Den_US
dc.titleThe association of Intron 4 VNTR and Glu298Asp polymorphisms of the nitric oxide synthetase 3 gene and vasculogenic erectile dysfunction in Turkish menen_US
dc.typeArticleen_US

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