Factors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experience

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dc.authoridOdabas, Hatice/0000-0002-5757-4705
dc.authoridAlkan Şen, Gülin/0000-0003-4658-1552;
dc.authorwosidOdabas, Hatice/HOH-1716-2023
dc.authorwosidAlkan Şen, Gülin/KJR-8384-2024
dc.authorwosidturan, nedim/GXG-8035-2022
dc.authorwosidAy, Murat/GSI-4353-2022
dc.contributor.authorAyhan, Murat
dc.contributor.authorOdabas, Hatice
dc.contributor.authorTuran, Nedim
dc.contributor.authorOzyukseler, Deniz Tataroglu
dc.contributor.authorKostek, Osman
dc.contributor.authorAlkan, Gulin
dc.contributor.authorAbamor, Evrim
dc.date.accessioned2024-06-12T10:55:34Z
dc.date.available2024-06-12T10:55:34Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe main objective is to define the mortality of patients with cancer admitted to our hospital, their clinical and demographic characteristics, investigate the risk of COVID-19 for patients with cancer, and determine factors that affect the mortality rates of patients with cancer dying of COVID-19. A total of 2401 patients were admitted to our hospital with the diagnosis of COVID-19 from March 11th, 2020, to May 31st, 2020. Ninety-two out of a total of 112 cancer patients were included in this study based on the planned inclusion/exclusion criteria. The clinical, demographic, and laboratory features and treatments provided were studied, and their effect on mortality rates was analyzed. In our study the median age of the patients was 67 years, and 55.4% were male. More than half (56.5%) of our patients had metastasis. The mortality rate was 6.2% in the overall population with COVID-19, whereas it was 23.9% in patients with cancer. The mortality rate in patients with metastasis was statistically significantly higher compared with those without metastasis (34.0% vs. 10.3% P = 0.008). The mortality rate in patients still smoking was statistically significantly higher than in non-smokers (37.5% vs. 12.5% P = 0.033). The mortality rates of patients with high average C-reactive protein (CRP), ferritin, lactate dehydrogenase (LDH), and D-dimer levels were statistically significantly higher than in those without, and the mortality rates of patients with lower average albumin and hemoglobin levels were statistically significantly higher than those without (P < 0.001, P = 0.006, P = 0.041, P < 0.001, P < 0.001, and P = 0.028, respectively). Having metastases concurrent with COVID-19 was a statistically significant factor predictive of prognosis. Also, high CRP, ferritin, LDH, and D-dimer, and low albumin and hemoglobin were related to increased mortality rates. The predictive and prognostic role of possible factors related to prognosis is still unknown and further large, multicenter prospective studies are needed to confirm these results.en_US
dc.identifier.doi10.1080/1120009X.2021.1923153
dc.identifier.endpage508en_US
dc.identifier.issn1120-009X
dc.identifier.issn1973-9478
dc.identifier.issue7en_US
dc.identifier.pmid34032198en_US
dc.identifier.startpage499en_US
dc.identifier.urihttps://doi.org/10.1080/1120009X.2021.1923153
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19475
dc.identifier.volume33en_US
dc.identifier.wosWOS:000654256600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Chemotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectCOVID-19en_US
dc.subjectMortality Rateen_US
dc.subjectMetastatic Stageen_US
dc.subjectSmokingen_US
dc.subjectTreatmenten_US
dc.subjectClinical Characteristicsen_US
dc.subjectPneumoniaen_US
dc.titleFactors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experienceen_US
dc.typeArticleen_US

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