Serum agouti-related protein (AgRP) levels in bipolar disorder: Could AgRP be a state marker for mania?

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dc.authorid, Rugül/0000-0003-2596-0473
dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosidPARLAK, EBRU S/O-6010-2018
dc.authorwosid, Rugül/AAI-1711-2019
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorParlak, Naci
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorSonmez, Mehmet Bulent
dc.contributor.authorParlak, Ebru
dc.date.accessioned2024-06-12T10:54:42Z
dc.date.available2024-06-12T10:54:42Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOrexigenic and anorexigenic peptides, especially agouti-related protein (AgRP) and leptin, play important roles in the regulation of energy homeostasis in bipolar disorder. AgRP regulates energy metabolism by increasing appetite and decreasing energy expenditure. The resting energy expenditures of patients with manic bipolar disorder are higher than those of controls. Due to the effects of AgRP on energy expenditure and the increased physical activity of manic patients, we hypothesised that serum AgRP levels may be lower in manic patients than in euthymic patients and controls. There was a total of 112 participants, including 47 patients in the manic group, 35 patients in the euthymic group and 30 healthy controls. For this study, serum AgRP, leptin, cholesterol, and cortisol levels were measured and compared between the groups. The serum AgRP, leptin, and cholesterol levels were significantly different between the groups. The serum AgRP levels of manic group were significantly lower than those of euthymic and control groups. The lower serum AgRP levels of manic patients could be indicators of impaired energy homeostasis during manic episodes. Since the serum AgRP levels of manic patients are lower than those of euthymic patients and controls, AgRP could be a state marker for manic episodes.en_US
dc.identifier.doi10.1016/j.psychres.2017.11.018
dc.identifier.endpage40en_US
dc.identifier.issn0165-1781
dc.identifier.issn1872-7123
dc.identifier.pmid29172096en_US
dc.identifier.scopus2-s2.0-85034426247en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage36en_US
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2017.11.018
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19150
dc.identifier.volume260en_US
dc.identifier.wosWOS:000424855300006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectAgouti-Related Proteinen_US
dc.subjectLeptinen_US
dc.subjectEnergy Metabolismen_US
dc.subjectState Markeren_US
dc.subjectManiaen_US
dc.subjectNeuropeptide-Yen_US
dc.subjectMitochondrial Dysfunctionen_US
dc.subjectPlasma-Levelsen_US
dc.subjectThyroid Axisen_US
dc.subjectBody-Weighten_US
dc.subjectLeptinen_US
dc.subjectExpressionen_US
dc.subjectSchizophreniaen_US
dc.subjectHomeostasisen_US
dc.subjectMetabolismen_US
dc.titleSerum agouti-related protein (AgRP) levels in bipolar disorder: Could AgRP be a state marker for mania?en_US
dc.typeArticleen_US

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