Clinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome An Observational Study

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dc.authoridMelikoglu, Meltem Alkan/0000-0001-7519-9470
dc.authoridMelikoglu, Melike/0000-0003-0253-8368
dc.authorwosidMelikoglu, Meltem Alkan/K-5695-2019
dc.authorwosidTutar, Burcin/AFV-8538-2022
dc.authorwosidSEYAHI, EMIRE/AAB-3576-2020
dc.authorwosidSeyahi, Emire/AAD-1769-2021
dc.authorwosidTuzun, Hasan/S-8478-2018
dc.contributor.authorSeyahi, Emire
dc.contributor.authorCakmak, Osman Serdal
dc.contributor.authorTutar, Burcin
dc.contributor.authorArslan, Caner
dc.contributor.authorDikici, Atilla Suleyman
dc.contributor.authorSut, Necdet
dc.contributor.authorKantarci, Fatih
dc.date.accessioned2024-06-12T11:18:41Z
dc.date.available2024-06-12T11:18:41Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVascular involvement can be seen in up to 40% of patients with Behcet syndrome (BS), the lower-extremity vein thrombosis (LEVT) being the most common type. The aim of the current study was to compare venous Doppler findings and clinical features between BS patients with LEVT and control patients diagnosed as having LEVT due to other causes.All consecutive 78 patients (71 men, 7 women; mean age 38.610.3 years) with LEVT due to BS and 50 control patients (29 men, 21 women; mean age 42.012.5 years) who had LEVT due to other causes, or idiopathic, were studied with the help of a Doppler ultrasonography after a detailed clinical examination. Patterns of venous disease were identified by cluster analyses. Clinical features of chronic venous disease were assessed using 2 classification systems. Venous claudication was also assessed.Patients with BS were more likely to be men, had significantly earlier age of onset of thrombosis, and were treated mainly with immunosuppressives and less frequently with anticoagulants. Furthermore, they had significantly more bilateral involvement, less complete recanalization, and more frequent collateral formation. While control patients had a disorganized pattern of venous involvement, BS patients had a contiguous and symmetric pattern, involving all deep and superficial veins of the lower extremities, with less affinity for crural veins. Clinical assessment, as measured by the 2 classification systems, also indicated a more severe disease among the BS patients. In line, 51% of the BS patients suffered from severe post-thrombotic syndrome (PTS) and 32% from venous claudication, whereas these were present in 8% and 12%, respectively, among the controls. Among BS patients, a longer duration of thrombosis, bilateral femoral vein involvement, and using no anticoagulation along with immunosuppressive treatment when first diagnosed were found to be associated independently with severe PTS.Lower-extremity vein thrombosis associated with BS, when compared to LEVT due to other causes, had distinctive demographic and ultrasonographic characteristics, and had clinically a more severe disease course.en_US
dc.identifier.doi10.1097/MD.0000000000001899
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue44en_US
dc.identifier.pmid26554787en_US
dc.identifier.scopus2-s2.0-84958236756en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000001899
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24919
dc.identifier.volume94en_US
dc.identifier.wosWOS:000369536100027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDeep Venous Thrombosisen_US
dc.subjectVascular Involvementen_US
dc.subjectPostthrombotic Syndromeen_US
dc.subjectThrombophilic Factorsen_US
dc.subjectRetrospective Analysisen_US
dc.subjectConsensus Statementen_US
dc.subjectRose Questionnaireen_US
dc.subjectDedicated Centeren_US
dc.subjectOutcome Surveyen_US
dc.subjectTime-Courseen_US
dc.titleClinical and Ultrasonographic Evaluation of Lower-extremity Vein Thrombosis in Behcet Syndrome An Observational Studyen_US
dc.typeArticleen_US

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