PROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteins

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dc.authoridSaygili, Seha Kamil/0000-0002-2424-6959
dc.authoridOzcelik, Gul/0000-0001-9394-2977
dc.authoridGedikbasi, Asuman/0000-0001-7121-6077
dc.authoridAğbaş, Ayşe/0000-0002-3658-8622
dc.authoridTaşdemir, Mehmet/0000-0002-5579-6339
dc.authoridYuruk Yildirim, Zeynep/0000-0003-2891-2231
dc.authorwosidakgul, sebahat usta/AAE-7495-2020
dc.authorwosidSaygili, Seha Kamil/GLU-6742-2022
dc.authorwosidOzcelik, Gul/GQQ-3364-2022
dc.authorwosidYuruk Yildirim, Zeynep Nagehan/AAE-1511-2020
dc.authorwosidTülpar, Sebahat/GQP-4951-2022
dc.authorwosidGedikbasi, Asuman/AAE-3613-2020
dc.authorwosidAğbaş, Ayşe/AAH-3650-2019
dc.contributor.authorYuruk Yildirim, Zeynep Nagehan
dc.contributor.authorUsta Akgul, Sebahat
dc.contributor.authorAlpay, Harika
dc.contributor.authorAksu, Bagdagul
dc.contributor.authorSavran Oguz, Fatma
dc.contributor.authorKiyak, Aysel
dc.contributor.authorAkinci, Nurver
dc.date.accessioned2024-06-12T10:56:26Z
dc.date.available2024-06-12T10:56:26Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractVarious molecular and cellular processes are involved in renal fibrosis, such as oxidative stress, inflammation, endothelial cell injury, and apoptosis. Heat shock proteins (HSPs) are implicated in the progression of chronic kidney disease (CKD). Our aim was to evaluate changes in urine and serum HSP levels over time and their relationships with the clinical parameters of CKD in children. In total, 117 children with CKD and 56 healthy children were examined. The CKD group was followed up prospectively for 24 months. Serum and urine HSP27, HSP40, HSP47, HSP60, HSP70, HSP72, and HSP90 levels and serum anti-HSP60 and anti-HSP70 levels were measured by ELISA at baseline, 12 months, and 24 months. The urine levels of all HSPs and the serum levels of HSP40, HSP47, HSP60, HSP70, anti-HSP60, and anti-HSP70 were higher at baseline in the CKD group than in the control group. Over the months, serum HSP47 and HSP60 levels steadily decreased, whereas HSP90 and anti-HSP60 levels steadily increased. Urine HSP levels were elevated in children with CKD; however, with the exception of HSP90, they decreased over time. In conclusion, our study demonstrates that CKD progression is a complicated process that involves HSPs, but they do not predict CKD progression. The protective role of HSPs against CKD may weaken over time, and HSP90 may have a detrimental effect on the disease course.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) within 1001-Scientific and Technological Research Projects Funding Program [115S365]en_US
dc.description.sponsorshipY This study was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK) within 1001-Scientific and Technological Research Projects Funding Program (project number:115S365).en_US
dc.identifier.doi10.1007/s12192-021-01239-9
dc.identifier.endpage987en_US
dc.identifier.issn1355-8145
dc.identifier.issn1466-1268
dc.identifier.issue6en_US
dc.identifier.pmid34671941en_US
dc.identifier.scopus2-s2.0-85117421252en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage973en_US
dc.identifier.urihttps://doi.org/10.1007/s12192-021-01239-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19788
dc.identifier.volume26en_US
dc.identifier.wosWOS:000709220700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCell Stress & Chaperonesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectCKDen_US
dc.subjectHeat Shock Proteinen_US
dc.subjectHSPen_US
dc.subjectProgressionen_US
dc.subjectHsp70en_US
dc.subjectExpressionen_US
dc.subjectCellsen_US
dc.subjectDegradationen_US
dc.subjectChaperonesen_US
dc.subjectApoptosisen_US
dc.subjectFibrosisen_US
dc.subjectMarkeren_US
dc.subjectDamageen_US
dc.subjectHsp47en_US
dc.titlePROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteinsen_US
dc.typeArticleen_US

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