Gingival Enlargement in Patients who Have Undergone Renal Transplants: A Meta-Analysis
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Indonesia, Fac Dentistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Severe gingival enlargement (GE) is one of the most commonly observed adverse effects in patients who have undergone renal transplants due to the use of cyclosporine A. Objectives: We aimed to gain more insight into the prevalence of GE in patients with renal transplants. Methods: We searched the PubMed and Web of Science databases for relevant studies from January 1990 to January 2018. Using random effects models, we calculated summary incidence rates and 95% confidence intervals (CIs). Results: A total of 595 patients from 10 studies were included. Patients using cyclosporine A with or without any other drugs had a 62.6% (95% CI, 41.9%-79.5%) incidence of GE. Subgroup analysis according to diagnostic criteria showed that the incidence of GE was lower when using well-defined diagnostic criteria or scoring system. The incidence of GE was 88.2% (95% CI, 80.9%-93.0%) in patients using cyclosporine A with nifedipine. Cyclosporine A without nifedipine was associated with a significantly decreased risk of GE incidence when compared with the combination of cyclosporine A and nifedipine (odds ratio: 0.198; 95% CI, 0.083-0.473; P < 0.001). Conclusions: It is important for all clinicians to know the effects of the aforementioned drugs and the treatment options.
Açıklama
Anahtar Kelimeler
Cyclosporine A, Gingival Enlargement, Gingival Overgrowth, Renal Transplantation, Cyclosporine-A, Allograft Recipients, Overgrowth, Nifedipine, Hyperplasia, Children, Parameters, Severity
Kaynak
Journal Of Dentistry Indonesia
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
25
Sayı
2
