The role of hepatobiliary scintigraphy in the evaluation of the protective effects of dimethylsulphoxide in ischaemic/reperfusion injury of liver

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dc.authoridSalihoglu, Yavuz Sami/0000-0003-2465-9128
dc.contributor.authorYüksel, M
dc.contributor.authorHatipoglu, A
dc.contributor.authorTemiz, E
dc.contributor.authorSalihoglu, YS
dc.contributor.authorHüseyinova, G
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:19:13Z
dc.date.available2024-06-12T11:19:13Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLiver ischaemia may lead to parenchymal damage depending on the duration of the ischaemia. Dimethylsulphoxide (DMSO), a well-known radical oxygen scavenger, is a protective agent against ischaemia/reperfusion injury. In this study we aimed to investigate the role of hepatobiliary scintigraphy (HBSc) in detecting the protective effect of DMSO. Eighteen rabbits, in three groups of six, were injected with 37 MBq technetium-99m-mebrofenin via the ear veins. Dynamic scintigrams were taken for 60 min (1 frame/min). In group A, HBSc was performed without any surgery. In groups B and C the Pringle manoeuvre (PM) was applied for 30 min, and tissue specimens for electron microscopy were taken from the liver parenchyma 5 min after the end of the PM. In addition, in group C 1 g/kg DMSO was injected into each rabbit 5 min before application of the PM. HBSc was then performed in groups 5 and C. From the dynamic images time-activity curves (TACs) were obtained for each group, and the time of peak uptake (TPU) and time for half of the activity to clear from the liver (T 1/2) were calculated. The TPU and T 1/2 of group B were significantly longer than those of groups A and C (P <0.0005 and P < 0.005 for TPU, and P<0.0005 and P<0.02 for T 1/2 respectively). The TPU and T 1/2 of group C were significantly longer than those of group A (P <0.005 and P<0.02, respectively). While the electron microscopic images in group C showed reversible changes, those in group B showed both irreversible and reversible changes. The electron microscopic findings of groups B and C confirmed the scintigraphic findings. In conclusion, HBSc might be used as a practical quantitative method for detecting the protective effects of DMSO. However, its clinical value should be evaluated by further studies with human subjects. ((C) 2000 Lippincott Williams & Wilkins).en_US
dc.identifier.doi10.1097/00006231-200008000-00012
dc.identifier.endpage780en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue8en_US
dc.identifier.pmid11039462en_US
dc.identifier.scopus2-s2.0-0034252923en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage775en_US
dc.identifier.urihttps://doi.org/10.1097/00006231-200008000-00012
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25120
dc.identifier.volume21en_US
dc.identifier.wosWOS:000088851900012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectFree-Radicalsen_US
dc.subjectHepatic-Functionen_US
dc.subjectOxygen Radicalsen_US
dc.subjectDamageen_US
dc.subjectTransplantationen_US
dc.subjectQuantificationen_US
dc.subjectCholestasisen_US
dc.subjectAnalogsen_US
dc.subjectBiopsyen_US
dc.titleThe role of hepatobiliary scintigraphy in the evaluation of the protective effects of dimethylsulphoxide in ischaemic/reperfusion injury of liveren_US
dc.typeArticleen_US

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